Produção Nacional
Revisado por pares
Glycans as Immune Checkpoints: Removal of Branched N-glycans Enhances Immune Recognition Preventing Cancer Progression
2020; American Association for Cancer Research; Volume: 8; Issue: 11 Linguagem: Inglês
10.1158/2326-6066.cir-20-0264
ISSN2326-6074
AutoresMariana Costa Silva, Ângela Fernandes, Maria José Oliveira, Carlos Resende, Alexandra Correia, Julio Cesar Madureira de‐Freitas‐Junior, Aonghus Lavelle, Jéssica Andrade-da-Costa, Magdalena Leander, Helena Xavier‐Ferreira, José Bessa, Carina Pereira, Rui Henrique, Fátima Carneiro, Mário Dinis‐Ribeiro, Ricardo Marcos‐Pinto, Margarida Lima, Bernd Lepenies, Harry Sokol, José Carlos Machado, Manuel Vilanova, Salomé S. Pinho,
Tópico(s)Galectins and Cancer Biology
ResumoTumor growth is accompanied with dramatic changes in the cellular glycome, such as the aberrant expression of complex branched N-glycans. However, the role of this protumoral N-glycan in immune evasion and whether its removal contributes to enhancement of immune recognition and to unleashing an antitumor immune response remain elusive. We demonstrated that branched N-glycans are used by colorectal cancer cells to escape immune recognition, instructing the creation of immunosuppressive networks through inhibition of IFNγ. The removal of this "glycan-mask" exposed immunogenic mannose glycans that potentiated immune recognition by DC-SIGN-expressing immune cells, resulting in an effective antitumor immune response. We revealed a glycoimmune checkpoint in colorectal cancer, highlighting the therapeutic efficacy of its deglycosylation to potentiate immune recognition and, thus, improving cancer immunotherapy.
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