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Prevalence of metabolic disturbances among women with polycystic ovary syndrome in different regions of Brazil

2020; Elsevier BV; Volume: 151; Issue: 3 Linguagem: Inglês

10.1002/ijgo.13374

1879-3479

Giovana De Nardo Maffazioli, Caroline Panone Lopes, Vanessa Heinrich‐Oliveira, Rogerio A. Løbo, Sylvia Asaka Yamashita Hayashida, José Maria Soares Júnior, Gustavo Arantes Rosa Maciel, Edmund Chada Baracat,

Reproductive Biology and Fertility

Abstract Objective To describe the prevalence of metabolic disturbances in a large cohort of women with polycystic ovary syndrome (PCOS) in southeastern Brazil and to compare the findings with other cohorts of Brazilian women with PCOS. Methods A retrospective study analyzing clinical and laboratory data of 462 women with PCOS treated at an outpatient clinic in a tertiary hospital in southeastern Brazil. Prevalence of insulin resistance, glucose intolerance, type 2 diabetes, dyslipidemia, central obesity, hypertension, and metabolic syndrome was compared to that of other cohorts of age and body mass index‐matched Brazilian women with PCOS. Results Women with PCOS had a median age of 25.0 (21.0–29.0) years and BMI of 28.7 (23.9–34.0) kg/m 2 . Prevalence of insulin resistance, glucose intolerance, and type 2 diabetes varied from 39.6% to 55.0%, 7.2% to 28.1%, and 2.0% to 4.1%, respectively. Prevalence of central obesity, dyslipidemia due to decreased high‐density lipoprotein cholesterol, hypertriglyceridemia, and metabolic syndrome ranged from 57.8% to 66.4%, 54.1% to 70.4%, 22.9% to 35.1%, and 27.4% to 38.3%, respectively, which did not differ among regions in Brazil. Conclusion Prevalence of metabolic disturbances was high among Brazilian women with PCOS. This study suggests that, from a public health perspective, authorities in Brazil should be aware of and encourage screening for metabolic dysfunction in women with PCOS in all regions of the country.