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BIBTEX RIS

Mast Cells in Alveolar Septa of COVID-19 Patients: A Pathogenic Pathway That May Link Interstitial Edema to Immunothrombosis

2020; Frontiers Media; Volume: 11; Linguagem: Inglês

10.3389/fimmu.2020.574862

ISSN

1664-3224

Autores

Jarbas da Silva Motta, Anna Flavia Ribeiro dos Santos Miggiolaro, Seigo Nagashima, Caroline Busatta Vaz de Paula, Cristina Pellegrino Baena, Júlio Scharfstein, Lúcia de Noronha,

Tópico(s)

Eosinophilic Disorders and Syndromes

Resumo

It is currently believed that innate immunity is unable to prevent the spread of SARS-CoV-2 from the upper airways to the alveoli of high-risk groups of patients. SARS-CoV-2 replication in ACE-2-expressing pneumocytes can drive the diffuse alveolar injury through the cytokine storm and immunothrombosis by upregulating the transcription of chemokine/cytokines, unlike several other respiratory viruses. Here we report histopathology data obtained in post-mortem lung biopsies of COVID-19, showing the increased density of perivascular and septal mast cells (MCs) and IL-4-expressing cells (

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