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Effect of air cleaners on early and late asthmatic response in asthmatic subjects sensitized to cat in ALYATEC’s environmental exposure chamber (EEC)

2020; Elsevier BV; Volume: 13; Issue: 8 Linguagem: Inglês

10.1016/j.waojou.2020.100212

1939-4551

F. de Blay, Nathalie Domis, Alina Gherasim,

Inhalation and Respiratory Drug Delivery

Indoor air quality is a growing concern. Air cleaners have been promoted in the treatment of respiratory allergic diseases for several decades. However, no clear clinical proof of their efficacy on allergic asthma has been demonstrated. The aim of the study was to assess the efficacy of air cleaners (Rowenta® Intense Pure Air XL) on early and late asthmatic response (EAR, LAR), in asthmatic subjects allergic to cat. 24 asthmatics subjects sensitized to cat (GINA 1) were enrolled in a randomized, cross-over, double-blind placebo-controlled study. They were exposed to airborne cat allergen for two hours during baseline exposure in Alyatec® EEC. Afterward, they were randomized in 2 groups exposed to cat allergen either with active or placebo air cleaners with a wash-out period of three weeks. 100% presented an EAR (20% drop in FEV1) and 25% a LAR (15% drop in FEV 1) during baseline exposure. The mean time necessary to obtain an EAR and LAR was 50.3 and 156 min, respectively. In placebo group, the frequency of EAR and LAR was not significantly different from the baseline (91.7 and 29.2% respectively). The time necessary to obtain an EAR and LAR was not significantly different. In active group, only 29.2% had an EAR and 16.7% had a LAR (p=0.0019). In the active group, 62.6% had neither EAR nor LAR. We have demonstrated that air cleaners Intense Pure Air XL® were able to reduce significantly the frequency of EAR and LAR in Alyatec’s EEC. For the first time, it has been shown that Air cleaners had a clinical effect in subjects allergic to cat.