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Local α1-adrenergic blockers: An alternative for sheep cervix dilation?

2020; Elsevier BV; Volume: 222; Linguagem: Inglês

10.1016/j.anireprosci.2020.106609

1873-2232

Luciana Cristina Padilha‐Nakaghi, Ricardo Andrés Ramírez Uscátegui, Maria Emília Franco Oliveira, Ricardo Perecin Nociti, Beatrice Ingrid Macente, Leandro Nassar Coutinho, Eduardo Y.O. Nakaghi, Guilherme Augusto Motta, Victor José Correia Santos, G. S. Maciel, Renata Sitta Gomes Mariano, Felipe Farias Pereira da Câmara Barros, Fernando Lucas Primo, Antônio Cláudio Tedesco, W. R. R. Vicente,

Reproductive Health and Contraception

To facilitate transcervical artificial insemination in sheep, the effects of local treatment with α1-adrenergic receptor antagonists on cervix dilation and hemodynamics were evaluated. Ewes (n = 7) were subjected to oestrous synchronisation every 40 days and assigned to treatments in a Latin square experimental design (seven animals × seven periods) with a factorial treatment arrangement (A × B), Factors A (prazosin or tamsulosin) and B (1, 2, or 4 mg/animal). Ewes of the six treatment groups (P1, P2, P4, T1, T2, and T4) were administered α1-adrenergic receptor antagonists while those of the control group (CG) were administered only α1-adrenergic antagonist carrier agent. Distance that the transcervical catheter penetrated without cervical resistance, mean arterial pressure, and uterine artery dopplerfluxometry were evaluated before and after 30 min, 1, 2, 4, 8, and 10 h of treatment. Catheter penetration distance was greater in ewes of the T4 and P4 groups (P < 0.01), with there being a positive correlation between dose and distance (r = 0.243). The penetration distance was similar (P = 0.84) for treated groups, with the greatest penetration occurring 2, 4, and 6 h after treatment (P < 0.01). The passage into the uterine lumen was greater (P = 0.013) in ewes of the P4 (17.9 %) and T4 (19.6 %) groups. There were no effects on blood pressure or uterine blood flow (P> 0.05). These preliminary results indicate there are benefits of treatment with 4 mg/animal of tamsulosin or prazosin in catheter passage through the sheep cervix 2–6 h after administration without hemodynamic effects.