Revisão Acesso aberto Revisado por pares

An update on the use of inositols in preventing gestational diabetes mellitus (GDM) and neural tube defects (NTDs)

2020; Taylor & Francis; Volume: 16; Issue: 12 Linguagem: Inglês

10.1080/17425255.2020.1828344

ISSN

1744-7607

Autores

Fabio Facchinetti, Pietro Cavalli, Andrew J. Copp, Rosario D’Anna, Eleni Kandaraki, Nicholas D. E. Greene, Vittorio Unfer,

Tópico(s)

Folate and B Vitamins Research

Resumo

Obstetric history and maternal body composition and lifestyle may be associated with serious complications both for the mother, such as gestational diabetes mellitus (GDM), and for the fetus, including congenital malformations such as neural tube defects (NTDs).In view of the recent knowledge, changes in nutritional and physical activity habits ameliorate glycemic control during pregnancy and in turn improve maternal and neonatal health outcomes. Recently, a series of small clinical and experimental studies indicated that supplemenation with inositols, a family of insulin sensitizers, was associated with beneficial impact for both GDM and NTDs.Herein, we discuss the most significant scientific evidence supporting myo-inositol administration as a prophylaxis for the above-mentioned conditions.

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