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Anti-glomerular Basement Membrane Disease: What Have We Learned?

2020; Lippincott Williams & Wilkins; Volume: 28; Issue: 1 Linguagem: Inglês

10.1097/pap.0000000000000280

1533-4031

Mohammed Akhtar, Noheir M. Taha, Muhammad Asim,

Renal Diseases and Glomerulopathies

Since the first clinicopathologic description by Ernest Goodpasture of a patient whom he considered to have died of influenza in 1919, substantial progress has been made in our knowledge of anti-glomerular basement membrane disease. This has led to a significant decrease in the morbidity and mortality associated with this disease. In this paper, we aim to review the literature that has enhanced our understanding of classic anti-glomerular basement membrane disease and its clinic-pathologic variants in the key areas of immunopathogenesis and histopathology. We also summarize varied clinical presentations and therapeutic strategies.