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Skin α-Synuclein Aggregation Seeding Activity as a Novel Biomarker for Parkinson Disease

2020; American Medical Association; Volume: 78; Issue: 1 Linguagem: Inglês

10.1001/jamaneurol.2020.3311

2168-6157

Zerui Wang, Katelyn Becker, Vincenzo Donadio, Sandra L. Siedlak, Jue Yuan, Masih Rezaee, Alex Incensi, Anastasia Kuzkina, Christina D. Orrù, Curtis Tatsuoka, Rocco Liguori, Steven A. Gunzler, Byron Caughey, Marı́a E. Jiménez-Capdeville, Xiongwei Zhu, Kathrin Doppler, Li Cui, Shu G. Chen, Jiyan Ma, Wen‐Quan Zou,

Neurological disorders and treatments

Deposition of the pathological α-synuclein (αSynP) in the brain is the hallmark of synucleinopathies, including Parkinson disease (PD), Lewy body dementia (LBD), and multiple system atrophy (MSA). Whether real-time quaking-induced conversion (RT-QuIC) and protein misfolding cyclic amplification (PMCA) assays can sensitively detect skin biomarkers for PD and non-PD synucleinopathies remains unknown.