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Amino Acid Substitutions Associated with Treatment Failure for Hepatitis C Virus Infection

2020; American Society for Microbiology; Volume: 58; Issue: 12 Linguagem: Inglês

10.1128/jcm.01985-20

1098-660X

María Eugenia Soria, Carlos García‐Crespo, Brenda Martínez‐González, Lucía Vázquez-Sirvent, Rebeca Lobo-Vega, Ana Isabel de Ávila, Isabel Gallego, Qian Chen, Damir García‐Cehic, Meritxell Llorens-Revull, Carlos Briones, Jordi Gómez, Cristina Ferrer‐Orta, Núria Verdaguer, Josep Gregori, Francisco Rodríguez‐Frías, Marı́a Buti, Juan Ignacio Esteban, Esteban Domingo, Josep Quer, Celia Perales,

HIV/AIDS drug development and treatment

Despite the high virological response rates achieved with current directly acting antiviral agents (DAAs) against hepatitis C virus (HCV), around 2% to 5% of treated patients do not achieve a sustained viral response. The identification of amino acid substitutions associated with treatment failure requires analytical designs, such as subtype-specific ultradeep sequencing (UDS) methods, for HCV characterization and patient management. Using this procedure, we have identified six highly represented amino acid substitutions (HRSs) in NS5A and NS5B of HCV, which are not bona fide resistance-associated substitutions (RAS), from 220 patients who failed therapy.