Immunogenicity evaluation of recombinant Lactobacillus casei W56 expressing bovine viral diarrhea virus E2 protein in conjunction with cholera toxin B subunit as an adjuvant
2020; BioMed Central; Volume: 19; Issue: 1 Linguagem: Inglês
10.1186/s12934-020-01449-3
ISSN1475-2859
AutoresShuo Jia, Xinning Huang, Hua Li, Dianzhong Zheng, Ge Li, Xinyuan Qiao, Yan-Ping Jiang, Wen Cui, Lijie Tang, Yijing Li, Yigang Xu,
Tópico(s)Transgenic Plants and Applications
ResumoBovine viral diarrhea virus (BVDV) is one of the main causes of infectious diseases in cattle and causes large financial losses to the cattle industry worldwide. In this study, Lactobacillus casei strain W56 (Lc W56) was used as antigen deliver carrier to construct a recombinant Lactobacillus vaccine pPG-E2-ctxB/Lc W56 constitutively expressing BVDV E2 protein fused with cholera toxin B subunit (ctxB) as an adjuvant, and its immunogenicity against BVDV infection in mice model by oral route was explored.
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