Kidney Failure Associates With T Cell Exhaustion and Imbalanced Follicular Helper T Cells
2020; Frontiers Media; Volume: 11; Linguagem: Inglês
10.3389/fimmu.2020.583702
ISSN1664-3224
AutoresSusan Hartzell, Sofia Bin, Chiara Cantarelli, Meredith Haverly, Joaquín Manrique, Andrea Angeletti, Gaetano La Manna, Barbara Murphy, Weijia Zhang, Josh Levitsky, Lorenzo Gallon, Samuel Mon-Wei Yu, Paolo Cravedi,
Tópico(s)T-cell and B-cell Immunology
ResumoIndividuals with kidney failure are at increased risk of cardiovascular events, as well as infections and malignancies, but the associated immunological abnormalities are unclear. We hypothesized that the uremic milieu triggers a chronic inflammatory state that, while accelerating atherosclerosis, promotes T cell exhaustion, impairing effective clearance of pathogens and tumor cells. Clinical and demographic data were collected from 78 patients with chronic kidney disease (CKD) (
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