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Emulating a target trial in case-control designs: an application to statins and colorectal cancer

2020; Oxford University Press; Volume: 49; Issue: 5 Linguagem: Inglês

10.1093/ije/dyaa144

1464-3685

Barbra A. Dickerman, Xabier García‐Albéniz, Roger Logan, Spiros Denaxas, Miguel A. Hernán,

Genetic factors in colorectal cancer

Previous case-control studies have reported a strong association between statin use and lower cancer risk. It is unclear whether this association reflects a benefit of statins or is the result of design decisions that cannot be mapped to a (hypothetical) target trial (that would answer the question of interest).