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TAM and TIM receptors mRNA expression in Zika virus infected placentas

2020; Elsevier BV; Volume: 101; Linguagem: Inglês

10.1016/j.placenta.2020.09.062

1532-3102

Guilherme de Moraes Nobrega, Ana Paula Samogim, Pierina Lorencini Parise, Emanuella Meneses Venceslau, José Paulo de Siqueira Guida, Rodolfo Rosa Japecanga, Mariene R. Amorim, Daniel A. Toledo-Teixeira, Julia Forato, Sílvio Roberto Consonni, Maria Laura Costa, José Luiz Proença-Módena, Eliana Amaral, Helaine Maria Besteti Pires Mayer-Milanez, Carolina C. Ribeiro‐do‐Valle, Roseli Calil, João Renato Bennini, Giuliane Jesus Lajos, Albina Altemani, Maria Luíza Moretti, Mariângela Ribeiro Resende, Márcia Teixeira Garcia, Rodrigo Nogueira Angerami, Marcos Tadeu Nolasco da Silva, Ana Carolina Coan, Maria Francisca Colella‐Santos, Andrea Paula Bruno von Zuben, André Ricardo Ribas Freitas, Marco Aurélio Ramirez Vinolo, Rodrigo Ramos Catharino, Fábio Trindade Maranhão Costa, Clarice Weis Arns, Aline Vieira, Gabriela Fabiano de Souza, Karina Bispo-dos-Santos, Mariene R. Amorim, Matheus Cavalheiro Martini, Stéfanie Primon Muraro,

Innovation and Socioeconomic Development

To investigate the role of TYRO3, AXL and TIM1 receptors in the Zika virus (ZIKV) cycle, we determined their mRNA expression in different placental sites of ZIKV infected tissue during pregnancy. Unexpectedly, the ZIKV infection was not related with mRNA upregulation of these receptors or changes in expression of type I and III interferons in different placental sites. Instead, a decrease of TYRO3 mRNA expression was observed in positive sites of ZIKV positive placentas in comparison to negative sites. The basis of this downregulation can help to understand how ZIKV persists in placental tissue during pregnancy.