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Antitumoral potential of carbamidocyclophanes and carbamidocylindrofridin A isolated from the cyanobacterium Cylindrospermum stagnale BEA 0605B

2020; Elsevier BV; Volume: 180; Linguagem: Inglês

10.1016/j.phytochem.2020.112529

1873-3700

Víctor Tena Pérez, Luis Apaza Ticona, Alfredo H. Cabanillas, Santiago Maderuelo Corral, Josefina Perles, Diego Fernando Rosero Valencia, Antera Martel Quintana, Montserrat Ortega Doménech, Ángel Rumbero Sánchez,

Cell death mechanisms and regulation

Three carbamidocyclophanes, A, F and V, and carbamidocylindrofridin A were isolated from the cultured freshwater cyanobacterium Cylindrospermum stagnale, collected in the Canary Islands. The chemical structures of these compounds were elucidated through NMR, HRMS and ECD spectroscopy. The absolute configuration of carbamidocyclophane A was confirmed using X-ray-diffraction. All compounds showed apoptotic capacity against the SK-MEL-1, SK-MEL-28 and SK-MEL-31 tumour cells. Carbamidocylindrofridin A had the highest anti-tumour potential, with an IC50 of 1 ± 0.3 μM in the SK-MEL-1 cell line.