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Maternal Immunological Adaptation During Normal Pregnancy

2020; Frontiers Media; Volume: 11; Linguagem: Inglês

10.3389/fimmu.2020.575197

1664-3224

Bahaa Abu-Raya, Christina Michalski, Manish Sadarangani, Pascal M. Lavoie,

Pregnancy and Medication Impact

The risk and severity of some specific infections are increased during pregnancy due to a combination of physiological and immunological changes. Characterizing the normal immunological adaptations during pregnancy is important to understand how the maternal immune system maintains tolerance towards the allogeneic fetus. This may also inform strategies to prevent maternal fatalities due to infections and optimize maternal vaccination to best protect the mother-fetus dyad and the infant after birth. In this review, we describe what is known about the immunological changes that occur during a normal pregnancy.