Portal de Periódicos da CAPES

Single-Cell Study of Two Rat Models of Pulmonary Arterial Hypertension Reveals Connections to Human Pathobiology and Drug Repositioning

2020; American Thoracic Society; Volume: 203; Issue: 8 Linguagem: Inglês

10.1164/rccm.202006-2169oc

1535-4970

Jason Hong, Douglas Arneson, Soban Umar, Grégoire Ruffenach, Christine M. Cunningham, In Sook Ahn, Graciel Diamante, May Bhetraratana, John F. Park, Emma Said, Caroline Huynh, Trixie Le, Lejla Medzikovic, Marc Humbert, Florent Soubrier, David Montani, Barbara Girerd, David‐Alexandre Trégouët, Richard N. Channick, Rajan Saggar, Mansoureh Eghbali, Xia Yang,

Extracellular vesicles in disease

The cellular and molecular landscape and translational value of commonly used models of pulmonary arterial hypertension (PAH) are poorly understood. Single-cell transcriptomics can enhance molecular understanding of preclinical models and facilitate their rational use and interpretation.