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BIBTEX RIS

Greater male than female variability in regional brain structure across the lifespan

2020; Wiley; Volume: 43; Issue: 1 Linguagem: Inglês

10.1002/hbm.25204

1097-0193

Lara M. Wierenga, Gaëlle E. Doucet, Danai Dima, Ingrid Agartz, Moji Aghajani, Theophilus N. Akudjedu, Anton Albajes‐Eizagirre, Dag Alnæs, Kathryn Alpert, Ole A. Andreassen, Alan Anticevic, Philip Asherson, Tobias Banaschewski, Núria Bargalló, Sarah Baumeister, Ramona Baur‐Streubel, Alessandro Bertolino, Aurora Bonvino, Dorret I. Boomsma, Stefan Borgwardt, Josiane Bourque, Anouk den Braber, Daniel Brandeis, Alan Breier, Henry Brodaty, Rachel M. Brouwer, Jan K. Buitelaar, Geraldo F. Busatto, Vince D. Calhoun, Erick J. Canales‐Rodríguez, Dara M. Cannon, Xavier Caseras, F. Xavier Castellanos, Tiffany M. Chaim‐Avancini, Christopher R. K. Ching, Vincent P. Clark, Patricia Conrod, Annette Conzelmann, Fabrice Crivello, Christopher G. Davey, Erin W. Dickie, Stefan Ehrlich, Dennis van ‘t Ent, Simon E. Fisher, Jean‐Paul Fouché, Barbara Franke, Paola Fuentes‐Claramonte, Eco J. C. de Geus, Annabella Di Giorgio, David C. Glahn, Ian H. Gotlib, Hans J. Grabe, Oliver Gruber, Patricia Gruner, Raquel E. Gur, Ruben C. Gur, Tiril P. Gurholt, Lieuwe de Haan, Beathe Haatveit, Ben J. Harrison, Catharina A. Hartman, Sean N. Hatton, Dirk J. Heslenfeld, Odile A. van den Heuvel, Ian B. Hickie, Pieter J. Hoekstra, Sarah Hohmann, Avram J. Holmes, Martine Hoogman, Norbert Hosten, Fleur M. Howells, Hilleke E. Hulshoff Pol, Chaim Huyser, Neda Jahanshad, Anthony James, Jiyang Jiang, Erik G. Jönsson, John A. Joska, Andrew Kalnin, Marieke Klein, Laura Koenders, Knut K. Kolskår, Bernd Krämer, Jonna Kuntsi, Jim Lagopoulos, Luisa Lázaro, И. С. Лебедева, Phil H. Lee, Christine Löchner, Marise W. J. Machielsen, Sophie Maingault, Nicholas G. Martin, Ignacio Martínez‐Zalacaín, David Mataix‐Cols, Bernard Mazoyer, Brenna C. McDonald, Colm McDonald, Andrew M. McIntosh, Katie L. McMahon, Genevieve McPhilemy, Dennis van der Meer, José M. Menchón, Jilly Naaijen, Lars Nyberg, Jaap Oosterlaan, Yannis Paloyelis, Paul Pauli, Giulio Pergola, Edith Pomarol‐Clotet, Marı́a J. Portella, Joaquim Raduà, Andreas Reif, Geneviève Richard, Joshua L. Roffman, Pedro GP Rosa, Matthew D. Sacchet, Perminder S. Sachdev, Raymond Salvador, Salvador Sarró, Theodore D. Satterthwaite, Andrew J. Saykin, Maurício H. Serpa, Kang Sim, Andrew Simmons, Jordan W. Smoller, Iris E. Sommer, Carles Soriano‐Mas, Dan J. Stein, Lachlan T. Strike, Philip R. Szeszko, Henk Temmingh, Sophia I. Thomopoulos, Alexander S. Tomyshev, Julian N. Trollor, Anne Uhlmann, Ilya M. Veer, Dick J. Veltman, Aristotle N. Voineskos, Henry Völzke, Henrik Walter, Lei Wang, Yang Wang, Bernd Weber, Wei Wen, John D. West, Lars T. Westlye, Heather C. Whalley, Steven Williams, Katharina Wittfeld, Daniel H. Wolf, Margaret J. Wright, Yuliya Yoncheva, Marcus V. Zanetti, Georg Ziegler, Greig I. de Zubicaray, Paul M. Thompson, Eveline A. Crone, Sophia Frangou, Christian K. Tamnes,

Birth, Development, and Health

For many traits, males show greater variability than females, with possible implications for understanding sex differences in health and disease. Here, the ENIGMA (Enhancing Neuro Imaging Genetics through Meta-Analysis) Consortium presents the largest-ever mega-analysis of sex differences in variability of brain structure, based on international data spanning nine decades of life. Subcortical volumes, cortical surface area and cortical thickness were assessed in MRI data of 16,683 healthy individuals 1-90 years old (47% females). We observed significant patterns of greater male than female between-subject variance for all subcortical volumetric measures, all cortical surface area measures, and 60% of cortical thickness measures. This pattern was stable across the lifespan for 50% of the subcortical structures, 70% of the regional area measures, and nearly all regions for thickness. Our findings that these sex differences are present in childhood implicate early life genetic or gene-environment interaction mechanisms. The findings highlight the importance of individual differences within the sexes, that may underpin sex-specific vulnerability to disorders.