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Impact of histological Oral Tongue Cancer margins on locoregional recurrence: A multi-centre retrospective analysis

2020; Elsevier BV; Volume: 111; Linguagem: Inglês

10.1016/j.oraloncology.2020.105004

1879-0593

James Daniell, Cristian Udovicich, David Rowe, Lachlan McDowell, Domenic Vital, Mathias Bressel, Matthew J. R. Magarey, Tim A. Iseli, Tim Wong, Ernest Lekgabe, Karda Cavanagh, Tsien Fua, Danny Rischin, D. Wiesenfeld,

Oral Health Pathology and Treatment

To assess the effect of the histological margins (HM) upon locoregional failure (LRF) and overall survival (OS) for oral tongue squamous cell carcinoma (OTSCC). We undertook a retrospective review of 258 patients, across two institutions, treated for OTSCC between 2007 and 2016. A Cox-proportional hazards model was used to compare the relative hazard ratio of HM to the accepted standard of 5 mm margins for LRF and OS. The median follow up period was 4.8 years. The 5 year OS and freedom from LRF were 69% and 75% respectively. The Cox-proportional hazards model adjusted for age, DOI and LVI showed increasing risk of mortality and LRF with decreasing HM widths of 5 mm were associated with a risk reduction of both LRF and mortality in OTSCC. This study supports >5 mm HM being the oncologic goal of surgery.