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Effectiveness of Voluntary Medical Male Circumcision for Human Immunodeficiency Virus Prevention in Rakai, Uganda

2020; Oxford University Press; Volume: 73; Issue: 7 Linguagem: Inglês

10.1093/cid/ciaa1533

1537-6591

Gideon Loevinsohn, Godfrey Kigozi, Joseph Kagaayi, Maria J. Wawer, Fred Nalugoda, Larry W. Chang, Thomas C. Quinn, David Serwadda, Steven J. Reynolds, Lisa Nelson, Lisa A. Mills, Stella Alamo, Gertrude Nakigozi, Geoffrey Kabuye, Robert Ssekubugu, Aaron A.R. Tobian, Ronald H. Gray, M. Kate Grabowski, Dorean Nabukalu, Anthony Ndyanabo, Joseph Ssekasanvu, Hadijja Nakawooya, Jessica Nakukumba, Grace Kigozi, Betty Nantume, Nampijja Resty, Jedidah Kambasu, Margaret Nalugemwa, Regina Nakabuye, Lawrence Ssebanobe, Justine Nankinga, Adrian Kayiira, Gorreth Nanfuka, Ruth Ahimbisibwe, Stephen Tomusange, Ronald M. Galiwango, Sarah Kalibbali, Margaret Nakalanzi, Joseph Ouma Otobi, Denis Ankunda, Joseph Lister Ssembatya, John B. Ssemanda, Robert Kairania, Emmanuel Kato, Alice Kisakye, James Batte, James Ludigo, Abisagi Nampijja, Steven Watya, Nehemia Kighoma, Sr. Margaret Anyokot, Joshua Mwinike, George Kibumba, Paschal Ssebowa, George Mondo, Francis Wasswa, Agnes Nantongo, Rebecca Kakembo, Josephine Galiwango, Geoffrey Ssemango, Andrew D. Redd, John Santelli, Caitlin E. Kennedy, Jennifer A. Wagman, Tom Lutalo, Fred Makumbi, Nelson Sewankambo, Oliver Laeyendecker,

Urologic and reproductive health conditions

The efficacy of voluntary male medical circumcision (VMMC) for human immunodeficiency virus (HIV) prevention in men was demonstrated in 3 randomized trials. This led to the adoption of VMMC as an integral component of the United States President's Emergency Plan for AIDS Relief (PEPFAR) combination HIV prevention program in sub-Saharan Africa. However, evidence on the individual-level effectiveness of VMMC programs in real-world, programmatic settings is limited.