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Stop COVID Cohort: An Observational Study of 3480 Patients Admitted to the Sechenov University Hospital Network in Moscow City for Suspected Coronavirus Disease 2019 (COVID-19) Infection

2020; Oxford University Press; Volume: 73; Issue: 1 Linguagem: Inglês

10.1093/cid/ciaa1535

1537-6591

Daniel Munblit, Nikita Nekliudov, Polina Bugaeva, Oleg Blyuss, Maria Kislova, Ekaterina Listovskaya, Aysylu Gamirova, Anastasia Shikhaleva, Vladimir E. Belyaev, Peter Timashev, John O. Warner, Pasquale Comberiati, Christian Apfelbacher, Evgenii Bezrukov, Mikhail E. Politov, Andrey Yavorovskiy, E. L. Bulanova, Natalya Tsareva, С. Н. Авдеев, Валентина Капустина, Yu I Pigolkin, Emmanuelle A. Dankwa, Christiana Kartsonaki, Mark G. Pritchard, Victor Fomin, Andrey Svistunov, Denis Butnaru, Petr Glybochko, Anna Berbenyuk, Polina Bobkova, Semyon Bordyugov, Aleksandra Borisenko, Ekaterina Bugaiskaya, Olesya Druzhkova, Д Н Елисеев, Yasmin El-Taravi, Natalia Gorbova, Elizaveta Gribaleva, Rina Grigoryan, Shabnam Ibragimova, Khadizhat Kabieva, Alena Khrapkova, Natalia Kogut, Karina Kovygina, Margaret Kvaratskheliya, Maria Lobova, A. A. Lunicheva, Anastasia Maystrenko, Daria Nikolaeva, Anna Pavlenko, Olga Perekosova, Olga Romanova, Sokova Oi, V S Solovieva, Olga Spasskaya, Ekaterina Spiridonova, Olga Sukhodolskaya, Shakir Suleimanov, Nailya Urmantaeva, Olga Usalka, M. P. Zaikina, Anastasia A. Zorina, Nadezhda Khitrina,

COVID-19 and healthcare impacts

Abstract Background The epidemiology, clinical course, and outcomes of patients with coronavirus disease 2019 (COVID-19) in the Russian population are unknown. Information on the differences between laboratory-confirmed and clinically diagnosed COVID-19 in real-life settings is lacking. Methods We extracted data from the medical records of adult patients who were consecutively admitted for suspected COVID-19 infection in Moscow between 8 April and 28 May 2020. Results Of the 4261 patients hospitalized for suspected COVID-19, outcomes were available for 3480 patients (median age, 56 years; interquartile range, 45–66). The most common comorbidities were hypertension, obesity, chronic cardiovascular disease, and diabetes. Half of the patients (n = 1728) had a positive reverse transcriptase–polymerase chain reaction (RT-PCR), while 1748 had a negative RT-PCR but had clinical symptoms and characteristic computed tomography signs suggestive of COVID-19. No significant differences in frequency of symptoms, laboratory test results, and risk factors for in-hospital mortality were found between those exclusively clinically diagnosed or with positive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RT-PCR. In a multivariable logistic regression model the following were associated with in-hospital mortality: older age (per 1-year increase; odds ratio, 1.05; 95% confidence interval, 1.03–1.06), male sex (1.71; 1.24–2.37), chronic kidney disease (2.99; 1.89–4.64), diabetes (2.1; 1.46–2.99), chronic cardiovascular disease (1.78; 1.24–2.57), and dementia (2.73; 1.34–5.47). Conclusions Age, male sex, and chronic comorbidities were risk factors for in-hospital mortality. The combination of clinical features was sufficient to diagnose COVID-19 infection, indicating that laboratory testing is not critical in real-life clinical practice.