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Deep phenotyping of 34,128 adult patients hospitalised with COVID-19 in an international network study

2020; Nature Portfolio; Volume: 11; Issue: 1 Linguagem: Inglês

10.1038/s41467-020-18849-z

2041-1723

Edward Burn, Seng Chan You, Anthony G. Sena, Kristin Kostka, Hamed Abedtash, Maria Tereza Fernandes Abrahão, Amanda Alberga, Heba Alghoul, Osaid Alser, Thamir M. Alshammari, María Aragón, Carlos Areia, Juan M. Banda, Jaehyeong Cho, Aedín C. Culhane, Alexander Davydov, Frank DeFalco, Talita Duarte‐Salles, Scott L. DuVall, Thomas Falconer, Sergio Fernández‐Bertolín, Weihua Gao, Asieh Golozar, Jill Hardin, George Hripcsak, Vojtech Huser, Hokyun Jeon, Yonghua Jing, Chi Young Jung, Benjamin Skov Kaas‐Hansen, Denys Kaduk, Seamus Kent, Yeesuk Kim, Spyros Kolovos, Jennifer C. E. Lane, Hyejin Lee, Kristine E. Lynch, Rupa Makadia, Michael E. Matheny, Paras Mehta, Daniel R. Morales, Karthik Natarajan, Fredrik Nyberg, Anna Ostropolets, Rae Woong Park, Jimyung Park, Jose Posada, Albert Prats‐Uribe, Gowtham Rao, Christian Reich, Yeunsook Rho, Peter R. Rijnbeek, Lisa M. Schilling, Martijn J. Schuemie, Nigam H. Shah, Azza Shoaibi, Seok Young Song, Henry M. Spotnitz, Marc A. Suchard, Joel N. Swerdel, David Vizcaya, Salvatore Volpe, Haini Wen, Andrew E. Williams, Belay Birlie Yimer, Lin Zhang, Oleg Zhuk, Daniel Prieto‐Alhambra, Patrick Ryan,

COVID-19 epidemiological studies

Abstract Comorbid conditions appear to be common among individuals hospitalised with coronavirus disease 2019 (COVID-19) but estimates of prevalence vary and little is known about the prior medication use of patients. Here, we describe the characteristics of adults hospitalised with COVID-19 and compare them with influenza patients. We include 34,128 (US: 8362, South Korea: 7341, Spain: 18,425) COVID-19 patients, summarising between 4811 and 11,643 unique aggregate characteristics. COVID-19 patients have been majority male in the US and Spain, but predominantly female in South Korea. Age profiles vary across data sources. Compared to 84,585 individuals hospitalised with influenza in 2014-19, COVID-19 patients have more typically been male, younger, and with fewer comorbidities and lower medication use. While protecting groups vulnerable to influenza is likely a useful starting point in the response to COVID-19, strategies will likely need to be broadened to reflect the particular characteristics of individuals being hospitalised with COVID-19.