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Virological outcome among HIV infected patients transferred from pediatric care to adult units in Madrid, Spain (1997–2017)

2020; Nature Portfolio; Volume: 10; Issue: 1 Linguagem: Inglês

10.1038/s41598-020-70861-x

2045-2322

Carolina Beltrán-Pavez, Miguel Gutiérrez-López, Marina Rubio-Garrido, Ana Valadés-Alcaraz, Luis Prieto, José Tomás Ramos, Santiago Jiménez de Ory, Marisa Navarro, Cristina Díez-Romero, Federico Pulido, Eulalia Valencia, África Holguín, María José Mellado, Luis Escosa, Milagros García López Hortelano, Talía Sainz, María Isabel González-Tomé, Pablo Rojo, Daniel Blázquez‐Gamero, Luis Prieto, Cristina Epalza, José Tomás Ramos, Sara Guillén, María Luisa Navarro, Jesús Saavedra, Mar Santos, Begoña Santiago, David Aguilera‐Alonso, Santiago Jiménez de Ory, Itzíar Carrasco, Miguel Ángel Roa, María Penín, Jorge Martínez, Katie Badillo, Eider Oñate, Itziar Pocheville, Elisa Garrote, Elena Colino, Jorge Gómez Sirvent, M. González-Ripoll Garzón, Vicente Román, Raquel Ferrer Angulo, Olaf Neth, Lola Falcón-Neyra, Pedro Terol, Juan Luis Santos, David Moreno, Francisco Lendínez, Estrella Peromingo, J. Uberos, Beatriz Ruiz, Ana María Gandarillas Grande, Francisco J. Romero, Carlos Pérez, Miguel Lillo, Begoña Losada, Mercedes Herranz, Matilde Bustillo Alonso, Pilar Collado, José Antonio Couceiro, Leticia Vila, Consuelo Calviño, Ana Isabel Piqueras, Manuel Oltra, César Gavilán, Elena Montesinos, Marta Dapena, Cristina Álvarez, Beatriz Jiménez, Ana Gloria Andrés, Víctor Marugán, Carlos Ochoa, Santiago Alfayate, Ana Ruiz, Y. Ruiz del Prado, Pere Soler‐Palacín, Marie Antoinette Frick, Antonio Mǔr, N. López Segura, María Luaces, Lluís Mayol, Teresa Vallmanya, Olga Calavia, Lourdes García, María Teresa Balaguer Coll, Valentí Pineda, Neus Rius, Joaquín Dueñas, Clàudia Fortuny, Antoni Noguera‐Julián, José Ignacio Bernardino, Marisa Montes, Eulalia Valencia, Rafael Rubio, Federico Pulido, Otilia Bisbal, Gabriel Gaspar Alonso, Juan Berenguer, Cristina Díez, Teresa Aldámiz, Pedro Montilla, Elena Bermúdez, Maricela Valerio, José Sanz, Sari Arponen, Alejandra Gimeno, Miguel Cervero, Rafael Torres, Santiago Moreno, Ma Jesús Pérez, Pablo Ryan, Jesús Troya, Jesús Sanz, Juan Emilio Losa, Rafael Hervás Gómez, José Antonio Iribarren, Francisco Rodríguez, Lydia Pascual, María José Aramburu, Ane Josune Goikoetxea, L Aguirrebengoa, Josefa Muñoz, Sofía Ibarra, Michele Hernández, Juan Luis Gómez Sirvent, Jehovana Rodríguez, Miguel Ángel Cárdenes, Luís F. López‐Cortés, Cristina Roca-Oporto, Silvia Llaves, María Rios, Jesús Rodríguez, Virginia Palomo, Juan Pasquau, Coral García, José Hernández, Clara Martínez, Antonio Rivero, Ángela Camacho, Dolores Merino, Elisa Martínez, Fernando Mateos, José Javier Blanch, Miguel Torralba, Piedad Arazo, Gloria Sampériz, María José Crusells, Isabel San Joaquín, Celia Miralles, Antonio Ocampo, Guille Pousada, Álvaro Mena, Marta Montero, Miguel Salavert, Sandra Cuéllar, Marı́a José Galindo, R Ferrando, Joaquín Portilla, Irene Portilla, Félix Gutiérrez, Mar Masiá, Cati Robledano, Araceli Adsuar, Carmen Hinojosa, P Bachiller, Jésica Abadía, José Luis Mostaza, Rosario Pérez, Carlos Galera, Helena Albendín, Aurora Rodríguez Pérez, José Ramón Blanco, Joaquín Burgos, Berta Torres, Elisa de Lazzari,

HIV Research and Treatment

Abstract The aim of this transversal study was to describe the virological and immunological features of HIV-infected youths transferred from pediatric to adult care units since 1997 vs. the non-transferred patients from the Madrid Cohort of HIV-infected children and adolescents in Spain. We included 106 non-transferred and 184 transferred patients under clinical follow-up in 17 public hospitals in Madrid by the end of December 2017. Virological and immunological outcomes were compared in transferred vs. non-transferred patients. ART drug resistance mutations and HIV-variants were analyzed in all subjects with available resistance pol genotypes and/or genotypic resistance profiles. Among the study cohort, 133 (72.3%) of 184 transferred and 75 (70.7%) of 106 non-transferred patients had available resistance genotypes. Most (88.9%) of transferred had ART experience at sampling. A third (33.3%) had had a triple-class experience. Acquired drug resistance (ADR) prevalence was significantly higher in pretreated transferred than non-transferred patients (71.8% vs. 44%; p = 0.0009), mainly to NRTI (72.8% vs. 31.1%; p < 0.0001) and PI (29.1% vs. 12%; p = 0.0262). HIV-1 non-B variants were less frequent in transferred vs. non-transferred (6.9% vs. 32%; p < 0.0001). In conclusion, the frequent resistant genotypes found in transferred youths justifies the reinforcement of HIV resistance monitoring after the transition to avoid future therapeutic failures.