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From more testing to smart testing: data-guided SARS-CoV-2 testing choices

2020; Cold Spring Harbor Laboratory; Linguagem: Inglês

10.1101/2020.10.13.20211524

Janko van Beek, Zsὁfia Iglὁi, Timo Boelsums, Ewout Fanoy, Hannelore M Götz, Richard Molenkamp, Jeroen J. A. van Kampen, Corine H. GeurtsvanKessel, Annemiek van der Eijk, David van de Vijver, Marion Koopmans,

Biosensors and Analytical Detection

Abstract We present an in-depth analysis of data from drive through testing stations using rapid antigen detection tests (RDT’s), RT-PCR and virus culture, to assess the ability of RDT’s to detect infectious cases. We show that the detection limits of five commercially available RDT’s differ considerably, impacting the translation into the detection of infectious cases. We recommend careful fit-for-purpose testing before implementation of antigen RDT’s in routine testing algorithms as part of the COVID-19 response.