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Novel Alzheimer Disease Risk Loci and Pathways in African American Individuals Using the African Genome Resources Panel

2020; American Medical Association; Volume: 78; Issue: 1 Linguagem: Inglês

10.1001/jamaneurol.2020.3536

2168-6157

Brian W. Kunkle, Michael A. Schmidt, Hans‐Ulrich Klein, Adam C. Naj, Kara L. Hamilton‐Nelson, Eric B. Larson, Denis A. Evans, Phil L. De Jager, Paul K. Crane, Joseph D. Buxbaum, Nilüfer Ertekin‐Taner, Lisa L. Barnes, M. Daniele Fallin, Jennifer J. Manly, Rodney C.P. Go, Thomas O. Obisesan, M. Ilyas Kamboh, David A. Bennett, Kathleen Hall, Alison Goate, Tatiana M. Foroud, Eden R. Martin, Li‐San Wang, Goldie S. Byrd, Lindsay A. Farrer, Jonathan L. Haines, Gerard D. Schellenberg, Richard Mayeux, Margaret A. Pericak‐Vance, Christiane Reitz, Erin L. Abner, M. Adams Perrie, L. Albin Roger, G Apostolova Liana, Eschrich Steven, S Craig, T. Baldwin Clinton, C. Barber Robert, Sandra Barral, Gunther Thomas, T. James, W. Beecham Gary, H. Bigio Eileen, D. Thomas, Deborah Blacker, F. Boeve Bradley, D. Bowen James, Adam Boxer, R. Burke James, Morris Jeffrey, J Cairns Nigel, Chuanhai Cao, M. Carlsson Cynthia, M. Carney Regina, M. Carrasquillo Minerva, Hugh-Jones David, Carlos Cruchaga, Malcom Dick, Dennis Wilmot, Rachelle S. Doody, Ranjan Duara, M. Faber Kelley, Jaya Thomas, B. Kenneth, W. Fardo David, Roger Martin, Steven H. Ferris, P. Frosch Matthew, R. Galasko Douglas, Marla Gearing, Hervé Daniel, Bernardino Ghetti, John Roshan, C. Green Robert, Harding John, Hákon Hákonarson, L. Hamilton Ronald, John Hardy, E. Harrell Lindy, Steve Lawrence, Mary Ryan, J. Huentelman Matthew, M Hulette Christine, P. Jarvik Gail, Lee‐Way Jin, Anna Karydas, J. Katz Mindy, S. John, C. Dirk Keene, Ronald Kim, H. Kramer Joel, J. Lah James, Yuk Yee Leung, Ge Li, Peter Andrew, B. Richard, G. Lyketsos Constantine, John Malamon, Chammiran Daniel, Frank Martiniuk, Eliezer Masliah, C. McCormick Wayne, M Susan, Nesbit M Andrew, Stefan McDonough, Canfield Ann., Marsel Mesulam, L. Miller Bruce, A. Miller Carol, J. Montine Thomas, Shubhabrata Mukherjee, J. Myers Amanda, E. O’Bryant Sid, M. Olichney John, E. Parisi Joseph, Elaine R. Peskind, Aimee Pierce, W. Poon Wayne, Huntington Potter, Liming Qu, F. Quinn Joseph, Ashok Raj, Murray A. Raskind, ‌Barry Reisberg, Joan Saló, M. Ringman John, D. Roberson Erik, Ekaterina Rogaeva, J. Rosen Howard, R. Royall Donald, A. Sager Mark, A. Schneider Julie, Su Lon, W. Seeley William, Scott A. Small, Joshua A. Sonnen, Salvatore Spina, Peter St George‐Hyslop, Aiko Robert, E. Tanzi Rudolph, Caballero Juan, W. Tsuang Debby, Otto Valladares, M. Van Deerlin Vivianna, Nabeel Badri, Vanessa Harry, Jean Paul Vonsattel, Sandra Weıntraub, A Welsh-Bohmer Kathleen, C W Kirk, Jennifer Williamson, SubinVarghese Thomas, Linnell Randall, Chuang‐Kuo Wu, G. Younkin Steven, Lei Yu, Chang‐En Yu, Yi Zhao, Neill R. Graff‐Radford, Izri Martinez, Temitope Ayodele, Mark W. Logue, Laura B. Cantwell, Melissa Jean‐Francois, Amanda Kuzma, Lonnie D. Adams, Jeffery M. Vance, Michael L. Cuccaro, Jaeyoon Chung, Jesse Mez, Kathryn L. Lunetta, Gyungah Jun, Oscar L. López, Hugh C. Hendrie, Eric M. Reiman, Neil W. Kowall, James B. Leverenz, Scott A. Small, Allan I. Levey, Todd E. Golde, Andrew J. Saykin, Takiyah D. Starks, Marilyn S. Albert, Bradley T. Hyman, Ronald Petersen, Mary Sano, Thomas Wısnıewskı, Robert Vassar, Jonathan Kaye, Victor W. Henderson, Charles DeCarli, Frank M. LaFerla, James B. Brewer, Bruce L. Miller, Russell H. Swerdlow, Linda J. Van Eldik, Henry L. Paulson, John Q. Trojanowski, Helena C. Chui, Roger N. Rosenberg, Suzanne Craft, Thomas J. Grabowski, Sanjay Asthana, John C. Morris, Stephen M. Strittmatter, Walter A. Kukull,

Neuroinflammation and Neurodegeneration Mechanisms

Compared with non-Hispanic White individuals, African American individuals from the same community are approximately twice as likely to develop Alzheimer disease. Despite this disparity, the largest Alzheimer disease genome-wide association studies to date have been conducted in non-Hispanic White individuals. In the largest association analyses of Alzheimer disease in African American individuals, ABCA7, TREM2, and an intergenic locus at 5q35 were previously implicated.