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Application of MWCNT/Ag‐Pt Nanocomposite Modified GCE for the Detection of Nevirapine in Pharmaceutical Formulation and Biological Samples

2020; Wiley; Volume: 32; Issue: 12 Linguagem: Inglês

10.1002/elan.202060374

1521-4109

Fredrick Okumu, Bongiwe Silwana, Mangaka C. Matoetoe,

Advanced biosensing and bioanalysis techniques

Abstract A study of nanosensor comprising of a glassy carbon electrode modified with a composite of multiwall carbon nanotube (MWCNT) and bimetallic (Ag‐PtNPs) for the determination of Nevirapine. The GCE/MWCNT/Ag‐PtNPs sensor had remarkable electrocatalytic properties with enhanced response towards Nevirapine under optimized conditions. The platform electrochemical characterisation in 0.01 M NaOH solution, with cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS) and differential pulse voltammetry (DPV) is detailed. The limit of the detection (LOD) was 0.021 μM. The nanosensor was validated for real sample study using spiked pharmaceutical dose form, milk and urine samples, which showed acceptable recoveries (90‐ 112 %), good precision (RSD=3.3 %, N=3), reproducibility (RSD=4.3 %) and excellent selectivity towards Nevirapine from studied interferents.