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Association of mild cognitive impairment and characteristic of COPD and overall health status in a cohort study

2020; Taylor & Francis; Volume: 15; Issue: 1 Linguagem: Inglês

10.1080/17476348.2021.1838278

1747-6356

Abebaw Mengistu Yohannes, Michelle N. Eakin, Janet T. Holbrook, Elizabeth A. Sugar, Robert J. Henderson, Anna M. Baker, Anne Casper, David A. Kaminsky, Alexis Rea, Anne M. Mathews, Loretta G. Que, Joe Ramsdell, Lynn B. Gerald, Robert A. Wise, Nicola A. Hanania,

Nursing Diagnosis and Documentation

Introduction: We evaluated risk factors and demographic characteristics of associated with mild cognitive impairment (MCI) in patients with COPD. Methods: 220 individuals with COPD enrolled in a cohort study designed to evaluate anxiety conducted at 16 clinical centers. Cognitive impairment was assessed with the Montreal Cognitive Assessment (MoCA), a cutoff score of <26 defined as MCI. Data were collected including spirometry, 6-minute walk test, symptom burden by COPD Assessment Test and dyspnea by Modified Medical Research Council, anxiety measured by Anxiety Inventory of Respiratory Disease, Generalized Anxiety Disorder-7 and Hospital Anxiety Depression Scale, depression by Patient Health Questionnaire-9 and health status by Patient Reported Outcomes Measurement Information System and sleep quality by the Pittsburg Sleep Quality Index. Results: The median age was 65 years and 54% of participants were male. 119(54%) of participants had MCI as classified by MoCA. In multivariable logistic regression, higher odds ratios (OR) (95% confidence interval) for MCI (MoCA) <26 were associated with increased years of age, 1.06 (1.02 -1-09, p<0.003); African-American race, 3.68(1.67-8.11, p<0.001); persistent phlegm, 2 (1.12-3.57, p<0.01) and sleep disturbance, 1.04(1.01-1.08, p<0.01). Conclusions: COPD patients commonly screen positive for MCI. Characteristics associated with MCI included age, African-American race, sleep disturbance and persistent phlegm.