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Mental Disorders in Peyronie’s Disease: A Swedish Cohort Study of 3.5 Million Men

2020; Lippincott Williams & Wilkins; Volume: 205; Issue: 3 Linguagem: Inglês

10.1097/ju.0000000000001426

1527-3792

Ralf Kuja‐Halkola, Lars Henningsohn, Brian M. D’Onofrio, Jesse N. Mills, Annsofie Adolfsson, Henrik Larsson, Martin Cederlöf,

Reproductive tract infections research

No AccessJournal of UrologyAdult Urology1 Mar 2021Mental Disorders in Peyronie's Disease: A Swedish Cohort Study of 3.5 Million MenThis article is commented on by the following:Editorial CommentEditorial Comment Ralf Kuja-Halkola, Lars Henningsohn, Brian M. D'Onofrio, Jesse Mills, Annsofie Adolfsson, Henrik Larsson, and Martin Cederlöf Ralf Kuja-HalkolaRalf Kuja-Halkola Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden , Lars HenningsohnLars Henningsohn Department of Clinical Science, Intervention, and Technology (CLINTEC), Karolinska Institutet, Stockholm, Sweden , Brian M. D'OnofrioBrian M. D'Onofrio Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden Department of Psychological and Brain Sciences, Indiana University, Bloomington, Indiana , Jesse MillsJesse Mills Department of Urology, David Geffen School of Medicine, University of California, Los Angeles, California , Annsofie AdolfssonAnnsofie Adolfsson School of Health Sciences, Örebro University, Örebro, Sweden , Henrik LarssonHenrik Larsson School of Medical Sciences, Örebro University, Örebro, Sweden , and Martin CederlöfMartin Cederlöf †Correspondence: Centre for Psychiatric Research, Norra stationsgatan 69, 11364, Stockholm, Sweden telephone: +46 (0)73 5678266; FAX: +46 (0)8311101; E-mail Address: [email protected] Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden School of Medical Sciences, Örebro University, Örebro, Sweden Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, & Stockholm Health Care Services, Stockholm, Sweden View All Author Informationhttps://doi.org/10.1097/JU.0000000000001426AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Studies have shown that men with Peyronie's disease often suffer from psychological problems, but the psychiatric burden of this disorder remains largely unknown. We assessed risks of a range of psychiatric outcomes in a population based Swedish cohort comprising 3.5 million men. Materials and Methods: We conducted a longitudinal cohort study based on Swedish national registers. A total of 8,105 men diagnosed with Peyronie's disease and 3.5 million comparison subjects from the general Swedish population were selected, and followed up with for diagnosed psychiatric outcomes including substance use disorder, alcohol misuse, anxiety disorder, depression, and self-injurious behaviors. Risks of psychiatric outcomes were estimated with Cox regressions and additionally adjusted for birth year. Results: Men with Peyronie's disease had increased risks of being diagnosed with substance use disorder (HR 1.4, 95% CI 1.1–1.9), no excess risk of alcohol misuse (HR 0.9, CI 0.8–1.1), but elevated risks of anxiety disorder (HR 1.9, CI 1.6–2.2), depression (HR 1.7, CI 1.5–2.0), self-injurious behaviors (HR 2.0, 95% CI 1.7–2.3) as well as any psychiatric outcomes (HR 1.4, 95% CI 1.2–1.5). The risk estimates were slightly decreased when adjusted for birth year. A limitation of the study was that we had no information about Peyronie's disease diagnoses assigned before year 1997. Conclusions: Men with Peyronie's disease are at increased risk of being diagnosed with adverse psychiatric outcomes. Health care providers should ensure that men with Peyronie's disease have a documented mental health status assessment. References 1. : François de la Peyronie (1978-1747): the man and the disease he described. BR J Urol 1996; 89: 613. 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Google Scholar © 2021 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited BySmith J (2020) This Month in Adult UrologyJournal of Urology, VOL. 205, NO. 3, (647-648), Online publication date: 1-Mar-2021.Related articlesJournal of UrologyJan 5, 2021, 12:00:00 AMEditorial CommentJournal of UrologyJan 5, 2021, 12:00:00 AMEditorial Comment Volume 205Issue 3March 2021Page: 864-870Supplementary Materials Advertisement Copyright & Permissions© 2021 by American Urological Association Education and Research, Inc.Keywordsmental disordersself-injurious behaviorspenile indurationcohort studiesMetricsAuthor Information Ralf Kuja-Halkola Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden More articles by this author Lars Henningsohn Department of Clinical Science, Intervention, and Technology (CLINTEC), Karolinska Institutet, Stockholm, Sweden More articles by this author Brian M. D'Onofrio Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden Department of Psychological and Brain Sciences, Indiana University, Bloomington, Indiana More articles by this author Jesse Mills Department of Urology, David Geffen School of Medicine, University of California, Los Angeles, California More articles by this author Annsofie Adolfsson School of Health Sciences, Örebro University, Örebro, Sweden Financial and/or other relationship with Orebro University. More articles by this author Henrik Larsson School of Medical Sciences, Örebro University, Örebro, Sweden More articles by this author Martin Cederlöf Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden School of Medical Sciences, Örebro University, Örebro, Sweden Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, & Stockholm Health Care Services, Stockholm, Sweden †Correspondence: Centre for Psychiatric Research, Norra stationsgatan 69, 11364, Stockholm, Sweden telephone: +46 (0)73 5678266; FAX: +46 (0)8311101; E-mail Address: [email protected] More articles by this author Expand All Advertisement Loading ...