Portal de Periódicos da CAPES

Consenso Mexicano de Mieloma Múltiple

2020; Academia Nacional de Medicina de México; Volume: 156; Issue: 92 Linguagem: Inglês

10.24875/gmm.m20000393

2696-1288

José A. de la Peña-Celaya, Jocelyn Aguilar-Luévano, Luisa M. Alcivar-Cedeño, José L. Álvarez-Vera, Irene Anaya-Cuéllar, Erika Añorve-Hernández, Luara L. Arana-Luna, Luis Arteaga-Ortíz, Pamela E. Báez-Islas, Luisa I. Banda-García, Ramón A. Bates-Martín, Dafne Itzel Campa-Monroy, Mariela Cardiel-Silva, Ángel de Jesús Castillo-Salas, Xóchitl Cota-Rangel, Guillermo Díaz-Vargas, María Eugenia Espitia-Ríos, Patricia Estrada-Domínguez, Denisse J. Fermín-Caminero, Alinka S. García-Camacho, Carolina García-Castillo, Katheryn B. Garzón-Velásquez, Carlos Gil-Rondero, Lidia V. Guerra-Alarcón, Ana K. Hernández-Colín, Eleazar Hernández-Ruiz, Areli E. Hernández-Alcántara, Silvia A. Hernández-Cervantes, Wilfrido Herrera-Olivares, Gregorio Ignacio-Ibarra, Sergio I. Inclán-Alarcón, Faustino Leyto-Cruz, Juan P. Macías-Flores, Andrea Martínez-de la Vega, Mario A. Martínez-Ramírez, Jorge A. Martínez-Coronel, Jesús E. Medina-Coral, Ma. Lizeth Meza-Dávalos, Leire Montoya-Jiménez, Alba E. Morales-Hernández, Elizabeth Morales-López, Javier Morales-Adrián, Maricruz Morales-de Azcué, Aldo Mújica-Martínez, Juan Murillo-Cruz, Jéssica Nájera-Martínez, Iris Narváez-Sarmiento, Lorena Nava-Villegas, Marco A. Nava-Alpide, Juan J. Orellana-Garibay, Ma. Teresa Palafox-Zaldívar, Orlando G. Palma-Moreno, Eugenia Patricia Paredes-Lozano, Ma. Luisa Pedraza-Colín, Juan Manuel Pérez-Zúñiga, Alejandra B. Pérez-Lizardi, Flavio Rojas-Castillejos, Eduardo Romero-Martínez, Hilda Romero-Rodelo, Josué I. Ruiz-Contreras, Azucena Saavedra-González, Erick E. Saucedo-Montes, Luis G. Silva-Michel, Karina Silva-Vera, Óscar Teomitzi-Sánchez, Fredy Tepepa-Flores, Yanet Ventura-Enríquez, Atenas Villela-Peña, Shendel P. Vilchis-González, Nidia Zapata-Canto, Pedro A. Zárate-Rodríguez, Martha Alvarado‐Ibarra,

Protein Degradation and Inhibitors

To identify this increasingly common pathology, known as multiple myeloma (MM), it is necessary to refer to the specific factors that characterize it; to this end, the classic criteria known as CRAB (hyperkalemia, renal failure, anemia, and lytic lesions) are available, in which renal failure is one of the most frequent complications.Recently, three indisputable biomarkers have been described for the diagnostic support for MM, which are: more than 10% of clonal plasma cells in bone marrow or, a biopsy that corroborates the presence of a plasmacytoma, light chain ratio ≥ 100 mg/dL and more than one focal lesion on magnetic resonance imaging.A differential diagnosis for plasma cell leukemia, solitary bone plasmacytoma, and extramedullary plasmacytoma should always be considered.Being this an incurable disease, a lot of research has been done regarding its therapeutic management, whose main objective is the disappearance of plasma cells and the patient clinical improvement.Melphalan was the first drug that showed a benefit in 1958 and afterward, with the addition of a steroid as a second drug, it was possible to improve response rates.Subsequently, different molecules were studied, forming multiple combinations, and achieving better rates of overall survival and progression-free survival.Years later, with the arrival of proteasome inhibitors such as bortezomib, and immunomodulators such as thalidomide and lenalidomide, an important turnaround in the disease has been seen, as deeper responses, more prolonged remissions, and improvement in the quality of life of patients have been achieved.This consensus has the purpose of integrating a group of Mexican specialists and promoting the updating of this pathology.