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pHLA3D: Updating the database of predicted three-dimensional structures of HLA with HLA-DR, HLA-DQ and HLA-DP molecules

2020; Elsevier BV; Volume: 82; Issue: 1 Linguagem: Inglês

10.1016/j.humimm.2020.10.007

1879-1166

Deylane Menezes Teles e Oliveira, Mário Sérgio Coelho Marroquim, Rafael Melo Santos de Serpa Brandão, Luiz Cláudio Demes da Mata Sousa, Francisco das Chagas Alves Lima, Semíramis Jamil Hadad do Monte, Antonio Vanildo de Sousa Lima, Antônio Gilberto Borges Coelho, Jhonatan Matheus Sousa Costa, Ricardo Martins Ramos, Ester Miranda Pereira, Adalberto Socorro da Silva,

Immunotherapy and Immune Responses

To improve the availability of three-dimensional (3D) structures of HLA molecules, we created the pHLA3D database. In its first version, we modeled and published 106 3D structures of HLA class I molecules from the HLA-A, HLA-B, and HLA-C loci. This paper presents an update of this database, providing more 127 3D structures of HLA class II molecules (41 DR, 42 DQ, and 44 DP), predicted via homology modeling with MODELLER and SWISS-MODEL. These new 3D structures of HLA class II molecules are now freely available at pHLA3D (www.phla3d.com.br) for immunologists and other researchers working with HLA molecules.