Superhero Genes in Axolotl Limb Regeneration: Could Deadpool be Real?
2020; Volume: 3; Issue: 11 Linguagem: Inglês
10.31080/asmi.2020.03.0723
ISSN2581-3226
AutoresAtakan Z Namli, Zeynep Gencyigit,
Tópico(s)Developmental Biology and Gene Regulation
ResumoAxolotls (Ambystoma Mexicanum) are vertebrates that have the ability to limb regeneration their body parts compared to most of other living populations.How this regeneration process works, how its mechanism takes place, and how blastemas are formed during differentiation are still being studied by researchers.Therewithal, it is known that many genes have significant effects in this regeneration process.Tgf-β1, Fgf-8, Pax3 and Pax7, Lin28, Msx-2, HGF, Hoxb13 and Hoxc10 are some of these genes.It is also observed that some genes involved in the regeneration process in the human liver are common with some genes involved in limb regeneration in axolotls.Understanding this limb regeneration that occurs in axolotls is thought to have an inspiring importance in the treatment of limb amputation or loss as a result of various traumas in humans, especially in tissue engineering and regenerative medicine.
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