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The global impact of SARS-CoV-2 in 181 people with cystic fibrosis

2020; Elsevier BV; Volume: 19; Issue: 6 Linguagem: Inglês

10.1016/j.jcf.2020.10.003

1873-5010

Elliot McClenaghan, Rebecca Cosgriff, K. Brownlee, Susannah Ahern, Pierre‐Régis Burgel, Catherine A. Byrnes, Carla Colombo, Harriet Corvol, Stephanie Y. Cheng, Géraldine Daneau, Alexander Elbert, Albert Faro, Christopher H. Goss, Vincent Gulmans, Hector Gutierrez, Isabelle de Monestrol, Andreas Jung, Lutz Nährlich Justus, N. Kashirskaya, Bruce C. Marshall, Edward F. McKone, Peter G. Middleton, Pedro Mondéjar-López, María Dolores Pastor‐Vivero, Rita Padoan, Samar Rizvi, Rasa Ruseckaite, Marco Salvatore, Anne L. Stephenson, Luiz Vicente R. da Silva Filho, Joel Melo, Marco Zampoli, S.B. Carr, Scott C. Bell, David W. Reid, Peter Wark, Eva Van Braeckel, Sophie Gohy, Christiane Knoop, Jessica Pirson, Elke De Wachter, Lieven Dupont, L. Hanssens, Vicky Nowé, Monique Lequesne, Rodrigo Abensur Athanazio, Daniela Góis Meneses, V. Boussaud, Graziella Brinchault, Emmanuelle Coirier-Duet, J.‐C. Dubus, Dominique Grenet, Sandra de Miranda, L. Beaumont, Reem Kanaan, Muriel Lauraens, C. Martín, Marie Mittaine Martin, Anne Prévötat, Martine Reynaud‐Gaubert, Isabelle Sermet‐Gaudelus, Aurélie Tatopoulos, R. Chiron, Marie‐Laure Dalphin, M. Gérardin, Laurence Weiss, Nathalie Wizla, Sophie Ramel, Barry J. Plant, Cedric Gunaratnam, A. Jackson, Rosaria Casciaro, Francesca Lucca, Valeria Daccò, Anna Folino, Antonio Manca, Barbara Messore, Letizia Corinna Morlacchi, Giovanna Pisi, Piercarlo Poli, Annalisa Amato, Gianluca Ferrari, Karin de Winter- de Groot, Bart Luijk, Geertjan Wesseling, E. Kondratyeva, E. Zhekayte, E. Amelina, M. A. Mukhina, О. И. Симонова, Antonio Álvarez-Fernández, Amparó Solé, Isidoro Cortell‐Aznar, Rosa Girón, A. López Neyra, Isabel Ramos-Cancelo, Maite Lzaro-Carrasco, Marta Ruiz de Valbuena, C. Prados-Sánchez, J. Colomer, Silvia Gärtner, Layla Diab-Cáceres, M. Gilljam, Ulrika Lindberg, S. Diemer, Mark I. Allenby, Stephen Bourke, Susan C. Charman, Janet Collinson, Owen Dempsey, Sarah F. Denniston, Maya Desai, J. Duckers, C. Etherington, E. Gunn, Alex Higton, Timothy Ho, Jeremy Hull, Andrew Jones, R.I. Ketchell, Susan Madge, Anirban Maitra, Ghulam Mujtaba, E.F. Nash, D. Nazareth, Christopher J. O’Brien, Claire Onyon, Christopher Orchard, D. Peckham, Helen Rodgers, Nadia Shafi, Nicholas J. Simmonds, Kevin W Southern, Martin Walshaw, Danie Watson, J.L. Whitehouse,

COVID-19 and healthcare impacts

With the growing SARS-CoV-2 pandemic, we need to better understand its impact in specific patient groups like those with Cystic Fibrosis (CF). We report on 181 people with CF (32 post-transplant) from 19 countries diagnosed with SARS-CoV-2 prior to 13 June 2020. Infection with SARS-CoV-2 appears to exhibit a similar spectrum of outcomes to that seen in the general population, with 11 people admitted to intensive care (7 post-transplant), and 7 deaths (3 post-transplant). A more severe clinical course may be associated with older age, CF-related diabetes, lower lung function in the year prior to infection, and having received an organ transplant. Whilst outcomes in this large cohort are better than initially feared overall, possibly due to a protective effect of the relatively younger age of the CF population compared to other chronic conditions, SARS-CoV-2 is not a benign disease for all people in this patient group.