Synthesis and properties of GuNA purine/pyrimidine nucleosides and oligonucleotides
2020; Royal Society of Chemistry; Volume: 18; Issue: 46 Linguagem: Inglês
10.1039/d0ob01970d
ISSN1477-0539
AutoresShinji Kumagai, Hiroaki Sawamoto, Tomo Takegawa-Araki, Yuuki Arai, Shuhei Yamakoshi, Katsuya Yamada, Tetsuya Ohta, Eiji Kawanishi, Naohiro Horie, Takao Yamaguchi, Satoshi Obika,
Tópico(s)RNA Interference and Gene Delivery
ResumoFacile synthesis of GuNA (guanidine-bridged nucleic acid) phosphoramidites bearing thymine, adenine, guanine, and 5-methylcytosine nucleobases and a robust method for the preparation of GuNA-modified oligonucleotides are described.
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