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Alterações da ECA2 e Fatores de Risco para Gravidade da COVID-19 em Pacientes com Idade Avançada

2020; Sociedade Brasileira de Cardiologia (SBC); Volume: 115; Issue: 4 Linguagem: Inglês

10.36660/abc.20200487

1678-4170

Caio de Assis Moura Tavares, Thiago Junqueira Avelino‐Silva, Gil Benard, Francisco Akira Malta Cardozo, Juliana Ruiz Fernandes, Adriana Castello Costa Girardi, Wilson Jacob Filho,

COVID-19 and Mental Health

ACE2, SARS-CoV-2 Infection and Aging Abnormalities induced by aging in metabolic pathways may partly explain the higher rate of COVID-19 morbidity and mortality in elderly patients. These include those belonging to the renin-angiotensin system (RAS), given the crucial role that this system plays both in viral transmissibility and in the pathogenesis of acute lung injury and its most severe form: acute respiratory distress syndrome (ARDS). ACE2 is known to act as a receptor for SARS-CoV-2 1 structural protein S (spike), [...]