Aging-Induced Changes in Sperm DNA Methylation are Modified by Low Dose of Perinatal Flame Retardants
2021; Future Medicine; Volume: 13; Issue: 4 Linguagem: Inglês
10.2217/epi-2020-0404
ISSN1750-1911
AutoresJ. Richard Pilsner, Alex Shershebnev, Haotian Wu, Chelsea Marcho, О. П. Дрибноходова, Victoria Shtratnikova, Oleg Sergeyev, Alexander Suvorov,
Tópico(s)Dietary Effects on Health
ResumoAims: Paternal age is increasing in developed countries. Understanding of aging-related epigenetic changes in sperm is needed as well as factors that modify such changes. Materials & methods: Young pubertal and mature rats were exposed perinatally to vehicle or environmental xenobiotic 2,2′,4,4′-tetrabromodiphenyl ether. Epididymal sperm was reduced representation bisulfite sequenced. Differentially methylated regions (DMRs) were identified via MethPipe. Results: In control animals, 5319 age-dependent DMRs were identified. Age-related DMRs were enriched for embryonic development. In exposed rats, DNA methylation was higher in young and lower in mature animals then in controls. Conclusions: Sperm methylome undergoes significant age-dependent changes, which may represent a causal link between paternal age and offspring phenotype. Environmental xenobiotics can interfere with the natural process of epigenetic aging.
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