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Anti-inflammatory activity of glycolipids isolated from cyanobacterium Nodularia harveyana

2020; Taylor & Francis; Volume: 35; Issue: 24 Linguagem: Inglês

10.1080/14786419.2020.1837808

1478-6427

Víctor Tena Pérez, Luis Apaza Ticona, Alfredo H. Cabanillas, Santiago Maderuelo Corral, Diego Fernando Rosero Valencia, Antera Martel Quintana, Montserrat Ortega Doménech, Ángel Rumbero Sánchez,

Algal biology and biofuel production

Activity-guided fractionations from the freshwater cyanobacterium Nodularia harveyana led to the isolation of two monogalactosyldiacylglycerols (MGDG), two digalactosyldiacylglycerols (DGDG), two monoglucosyldiacylglycerols (MGlcDG) and 1-(O-hexose)-3,25-hexacosanediol (HG). Structures were elucidated by a combination of 1D and 2D NMR analysis, HRMS and GC-MS. The potential for inhibition against TNF-α and NF-κB production of these seven compounds was tested in THP-1 cells. All compounds showed activity, but compound 7 showed higher inhibitory activity of TNF-α and NF-κB, with IC50 of 4.88 ± 0.13 and 3.64 ± 0.45 μM, respectively.