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1,8-Cineole: a review of source, biological activities, and application

2020; Taylor & Francis; Volume: 23; Issue: 10 Linguagem: Inglês

10.1080/10286020.2020.1839432

1477-2213

Zimin Cai, Jianqing Peng, Yi Chen, Ling Tao, Yanyan Zhang, Lingyun Fu, Qing-De Long, Xiangchun Shen,

Natural product bioactivities and synthesis

1,8-Cineole (also known as eucalyptol) is mostly extracted from the essential oils of plants, which showed extensively pharmacological properties including anti-inflammatory and antioxidant mainly via the regulation on NF-κB and Nrf2, and was used for the treatment of respiratory diseases and cardiovascular, etc. Although various administration routes have been used in the application of 1.8-cineole, few formulations have been developed to improve its stability and bioavailability. This review retrospects the researches on the source, biological activities, mechanisms, and application of 1,8-cineole since 2000, which provides a view for the further studies on the application and formulations of 1,8-cineole.