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Identification of Common Deletions in the Spike Protein of Severe Acute Respiratory Syndrome Coronavirus 2

2020; American Society for Microbiology; Volume: 94; Issue: 17 Linguagem: Inglês

10.1128/jvi.00790-20

1098-5514

Zhe Liu, Huanying Zheng, Huifang Lin, Mingyue Li, Runyu Yuan, Jinju Peng, Qianling Xiong, Jiufeng Sun, Baisheng Li, Jie Wu, Lina Yi, Xiaofang Peng, Huan Zhang, Wei Zhang, Ruben J. G. Hulswit, Nicholas J. Loman, Andrew Rambaut, Changwen Ke, Thomas A. Bowden, Oliver G. Pybus, Jing Lu,

Viral gastroenteritis research and epidemiology

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel coronavirus first identified in December 2019. Notable features that make SARS-CoV-2 distinct from most other previously identified betacoronaviruses include a receptor binding domain and a unique insertion of 12 nucleotides or 4 amino acids (PRRA) at the S1/S2 boundary. In this study, we identified two deletion variants of SARS-CoV-2 that either directly affect the polybasic cleavage site itself (NSPRRAR) or a flanking sequence (QTQTN). These deletions were verified by multiple sequencing methods.