Produção Nacional
Revisado por pares
Safety and immunogenicity of 17DD attenuated yellow fever vaccine in howler monkeys ( Alouatta spp.)
2020; Wiley; Volume: 50; Issue: 1 Linguagem: Inglês
10.1111/jmp.12501
ISSN1600-0684
AutoresAndré T. Fernandes, Sílvia Bahadian Moreira, Luciane P. Gaspar, Marisol Simões, Ana Carolina dos Reis Albuquerque Cajaraville, Renata Carvalho Pereira, Mariana P. B. Gomes, José Linhares, Vanessa de Oliveira Santos, Renata Tourinho Santos, Juliana Fernandes Amorim da Silva, Tamiris Azamor, Juliana Gil Melgaço, Andréa Marques Vieira da Silva, Camilla Bayma Fernandes, Luciana Tubarão, Jane da Silva, Elena Caride, Maria Beatriz Borges, Rosane Cuber Guimarães, Renato Sérgio Marchevsky, Sheila Maria Barbosa de Lima, Ana Paula Dinis Ano Bom, Patrícia Neves, Alcides Pissinatti, Marcos da Silva Freire,
Tópico(s)Virology and Viral Diseases
ResumoAbstract Background Alouatta spp. are highly susceptible to yellow fever (YF) infection and develop an often fatal disease. The threat posed by an outbreak started in 2016 leads us to investigate vaccination as a potential tool in preventing YF in non‐human primates (NHP). Methods Susceptible howler monkeys were immunized with three different concentrations of the human Brazilian commercial YF17DD vaccine. Post‐vaccination viremia/RNAemia, immunogenicity, and safety were characterized. Results The vaccine did not produce YF clinical manifestations in any of the NHPs. After immunization, all animals seroconverted demonstrating the ability of the YF vaccine to induce humoral response in Alouatta species. Conclusions The present work has demonstrated the safe and immunogenic profile of the existing YF 17DD vaccine in howler monkeys. This knowledge may support further studies with other susceptible monkey species and provide a possible solution for controlling epizootics and preventing the devastation of endangered species.
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