Portal de Periódicos da CAPES

The six million dollar man

2020; European Respiratory Society; Volume: 7; Issue: 1 Linguagem: Inglês

10.1183/23120541.00341-2020

2312-0541

Mathilde Volpato, Stefan Nowak, J.L. Bourrain, P. Démoly, Engi Ahmed, Arnaud Bourdin, Jérémy Charriot,

Allergic Rhinitis and Sensitization

We report here the observation of a 60-year-old male jeweller who was suffering from severe asthma. Asthma onset was reported by age 30. The patient also reported comorbid severe chronic rhinosinusitis with nasal polyposis since adolescence. Aspirin and nonsteroidal anti-inflammatory drug intolerance was considered to worsen the patient's asthma symptoms, since he had experienced one episode of emergency room attendance shortly after aspirin ingestion. Episodes of generalised chronic urticaria led to genuine anaphylactic reactions that were treated with epinephrine twice in the past, but fortunately without the need for orotracheal intubation. No trigger for these episodes could be identified despite appropriate provocation tests. In this case report, relapse of urticaria after a switch from oma- to mepolizumab successfully led to combination of biologics