Telomere shortening as a stress-related biomarker in children exposed to maternal chronic stress in utero measured 7 years after the Great East Japan Earthquake
2020; Elsevier BV; Volume: 295; Linguagem: Inglês
10.1016/j.psychres.2020.113565
ISSN1872-7123
AutoresShuko Takahashi, Hiroaki Arima, Masayuki Nakano, Tomoharu Ohki, Jun Morita, Kiyoshi Tabata, Yoshihiro Takayama, Kozo Tanno, Taro Yamamoto,
Tópico(s)Selenium in Biological Systems
ResumoSeven years after the Great East Japan Earthquake, we investigated telomeres as a potential biomarker of maternal chronic stress in children according to the timing of exposure to the disaster. The subjects were children aged 5-9 years living in Rikuzentakata, Japan. Relative telomere length (rTL) was measured with PCR in saliva samples. The partial regression coefficient of the rTL was significantly shorter in the group of children conceived after the disaster than in the children who were in utero on the day of the disaster. Telomere length should be investigated as a biomarker for assessing disaster-related trauma in future studies.
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