Portal de Periódicos da CAPES

Artigo Produção Nacional Revisado por pares

BIBTEX RIS

Green Synthesis of Nano Hydroxyapatite: morphology variation and its effect on cytotoxicity against fibroblast

2020; Elsevier BV; Volume: 284; Linguagem: Inglês

10.1016/j.matlet.2020.129013

1873-4979

Andrea Elizabeth Melgar Aguilar, Ana Paula Fagundes, Domingos Lusitâneo Pier Macuvele, Karina Cesca, Luismar Marques Porto, Natan Padoin, Cíntia Soares, Humberto Gracher Riella,

Nanoparticle-Based Drug Delivery

Nano hydroxyapatite (nHA) was synthesized from different methods. Spherical-like shaped nanoparticles of nHA were synthesized by chemical precipitation using Euclea natalensis root extract as a template for the first time. In addition, traditional synthesis was performed, obtaining rod-like nanoparticles. The formation of nHA was confirmed using Fourier Transform Infrared (FTIR), X-Ray Diffraction (XRD), and Transmission Electron Microscopy (TEM). HA from green route presented a spherical-like shape with smooth surface. However, nanogrooves covered over the surface of nHA obtained without green template. Additionally, the cytotoxic effect of the nHA nanoparticles on L929 viability was assessed using MTS assay. The particles exhibited less cellular toxicity at shorter incubation periods. Spherical-like and rod-like nHA particles interact differently with fibroblast after 24 h of evaluation.