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The Emergency Surgery Frailty Index (EmSFI): development and internal validation of a novel simple bedside risk score for elderly patients undergoing emergency surgery

2020; Springer Science+Business Media; Volume: 33; Issue: 8 Linguagem: Inglês

10.1007/s40520-020-01735-5

1720-8319

Gianluca Costa, Laura Bersigotti, Giulia Massa, L Lepre, Pietro Fransvea, Alessio Lucarini, Paolo Mercantini, Genoveffa Balducci, Gabriele Sganga, Antonio Crucitti, Ferdinando Agresta, Giovanni Alemanno, Gabriele Anania, Massimo Antropoli, Giulio Argenio, Jenny Atzeni, Nicola Avenia, Antonio Azzinnaro, G. Baldazzi, Genoveffa Balducci, Giorgio Barbera, Giovanni Bellanova, Carlo Bergamini, Laura Bersigotti, Paolo Pietro Bianchi, Cristina Bombardini, Giuseppe Borzellino, Samantha Bozzo, Gioia Brachini, G. M. Buonanno, Tiberio Canini, S. Cardella, Giulia Carrara, Diletta Cassini, Maurizio Castriconi, Graziano Ceccarelli, D Celi, Marco Ceresoli, Massimo Chiarugi, Nicola Cillara, F Cimino, Luigi Cobuccio, Gianfranco Cocorullo, Ettore Colangelo, Gianluca Costa, Antonio Crucitti, Patrizia Dalla Caneva, M. De Luca, A De Manzoni Garberini, Carlo De Nisco, Marco De Prizio, A. De Sol, Annamaria Di Bella, T. Falcioni, Nicolò Falco, Claudio Farina, Elena Finotti, Tommaso Fontana, Gianfranco Francioni, Pietro Fransvea, Barbara Frezza, Giovanni Maria Garbarino, Gianluca Garulli, Michele Genna, Sandro Giannessi, A. Gioffrè, Alessio Giordano, Débora Gozzo, Simone Di Maria Grimaldi, Gaspare Gulotta, V. Iacopini, T Iarussi, Giovanni Guglielmo Laracca, E. Laterza, A. Leonardi, L Lepre, Laura Lorenzon, Gianluigi Luridiana, A. Malagnino, G. Mar, Pierluigi Marini, Rinaldo Marzaioli, G. Massa, Valerio Mecarelli, Paolo Mercantini, Andrea Mingoli, Giuseppe Nigri, Savino Occhionorelli, Nadiane Paderno, Gian Marco Palini, D. Paradies, Marino Paroli, Fabrizio Perrone, Niccolò Petrucciani, Luca Petruzzelli, Angela Pezzolla, Diego Piazza, V. Piazza, Micaela Piccoli, Adolfo Pisanu, Mauro Podda, Gaetano Poillucci, Raffaele Porfidia, G. Rossi, Paolo Ruscelli, Alessandra Spagnoli, R. Sulis, Dario Tartaglia, Cristian Tranà, Antonio Travaglino, Pasquina M. C. Tomaiuolo, Andrea Valeri, Giorgio Vasquez, Mauro Zago, E. Zanoni,

Hip and Femur Fractures

Abstract Background Frailty assessment has acquired an increasing importance in recent years and it has been demonstrated that this vulnerable profile predisposes elderly patients to a worse outcome after surgery. Therefore, it becomes paramount to perform an accurate stratification of surgical risk in elderly undergoing emergency surgery. Study design 1024 patients older than 65 years who required urgent surgical procedures were prospectively recruited from 38 Italian centers participating to the multicentric FRAILESEL (Frailty and Emergency Surgery in the Elderly) study, between December 2016 and May 2017. A univariate analysis was carried out, with the purpose of developing a frailty index in emergency surgery called “EmSFI”. Receiver operating characteristic curve analysis was then performed to test the accuracy of our predictive score. Results 784 elderly patients were consecutively enrolled, constituting the development set and results were validated considering further 240 consecutive patients undergoing colorectal surgical procedures. A logistic regression analysis was performed identifying different EmSFI risk classes. The model exhibited good accuracy as regard to mortality for both the development set (AUC = 0.731 [95% CI 0.654–0.772]; HL test χ 2 = 6.780; p = 0.238) and the validation set (AUC = 0.762 [95% CI 0.682–0.842]; HL test χ 2 = 7.238; p = 0.299). As concern morbidity, our model showed a moderate accuracy in the development group, whereas a poor discrimination ability was observed in the validation cohort. Conclusions The validated EmSFI represents a reliable and time-sparing tool, despite its discriminative value decreased regarding complications. Thus, further studies are needed to investigate specifically surgical settings, validating the EmSFI prognostic role in assessing the procedure-related morbidity risk.