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Gas dynamic virtual nozzle for generation of microscopic droplet streams

2008; Institute of Physics; Volume: 41; Issue: 19 Linguagem: Inglês

10.1088/0022-3727/41/19/195505

1361-6463

Daniel P. DePonte, Uwe Weierstall, K. E. Schmidt, Joel Warner, D. Starodub, John C. H. Spence, R. Bruce Doak,

Electrowetting and Microfluidic Technologies

As shown by Gañán-Calvo (1998 Phys. Rev. Lett. 80 285–8), a free liquid jet can be compressed in diameter through gas dynamic forces exerted by a coaxially co-flowing gas, obviating the need for a solid nozzle to form a microscopic liquid jet and thereby alleviating the clogging problems that plague conventional droplet sources of small diameter. We describe in this paper a novel form of droplet beam source based on this principle. The source is miniature, robust, dependable, easily fabricated, essentially immune to clogging and eminently suitable for delivery of microscopic liquid droplets, including hydrated biological samples, into vacuum for analysis using vacuum instrumentation. Monodisperse, single-file droplet streams are generated by triggering the device with a piezoelectric actuator.