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HBcAb Positivity Increases the Risk of Severe Hepatic Fibrosis Development in HIV/HCV-Positive Subjects From the ICONA Italian Cohort of HIV-Infected Patients

2020; Oxford University Press; Volume: 8; Issue: 1 Linguagem: Inglês

10.1093/ofid/ofaa566

2328-8957

Vincenzo Malagnino, Carlotta Cerva, Antonella Cingolani, Francesca Ceccherini‐Silberstein, Alessandra Vergori, Gianluca Cuomo, Carlo Federico Perno, Massimo Puoti, Antonella d’Arminio Monforte, Alessandro Cozzi‐Lepri, Massimo Andreoni, Loredana Sarmati, Antonella d’Arminio Monforte, Andrea Antinori, Massimo Andreoni, Antonella Castagna, Francesco Castelli, Roberto Cauda, Giovanni Di Perri, Massimo Galli, Rosaria Iardino, Giuseppe Ippolito, Adriano Lazzarin, Giulia Marchetti, G Rezza, F von Schloesser, P. Viale, Antonella d’Arminio Monforte, Andrea Antinori, Antonella Castagna, Francesca Ceccherini‐Silberstein, Alessandro Cozzi‐Lepri, Enrico Girardi, Andrea Gori, Sergio Lo Caputo, Franco Maggiolo, C Mussini, Massimo Puoti, Carlo Federico Perno, Andrea Antinori, Francesca Bai, Alessandra Bandera, Stefano Bonora, Marco Borderi, Andrea Calcagno, Maria Rosaria Capobianchi, Antonella Castagna, Francesca Ceccherini‐Silberstein, S Cicalini, Antonella Cingolani, Paola Cinque, Alessandro Cozzi‐Lepri, Antonella d’Arminio Monforte, Antonio Di Biagio, Roberta Gagliardini, Enrico Girardi, Nicola Gianotti, Andrea Gori, G Guaraldi, Giuseppe Lapadula, Miriam Lichtner, Alessia Lai, Sergio Lo Caputo, Giordano Madeddu, Franco Maggiolo, Giulia Marchetti, Esther Merlini, C Mussini, Silvia Nozza, Carlo Federico Perno, Stefania Piconi, Carmela Pinnetti, Massimo Puoti, Eugenia Quirós-Roldán, Roberto Rossotti, Stefano Rusconi, Maria Mercedes Santoro, Annalisa Saracino, Loredana Sarmati, Vincenzo Spagnuolo, Valentina Svicher, Lucia Taramasso, Alessandro Cozzi‐Lepri, Iuri Fanti, Laura Galli, Patrizia Lorenzini, A Rodano’, Marco Macchia, A Tavelli, Albert Bové, A. Camposeragna, Massimiliano Errico, Marco Manfredini, A Perziano, Valeria Calvino, Fabrizio Carletti, Silvia Carrara, Antonino Di, Silvia Graziano, F Petroni, Gennaro Prota, S Truffa, Andrea Giacometti, Andrea Costantini, V Barocci, Gioacchino Angarano, Laura Monno, Eugenio Milano, Franco Maggiolo, Claudia Suardi, P. Viale, Valentina Donati, G Verucchi, Filippo Castelnuovo, C Minardi, Eugenia Quirós-Roldán, Barbara Menzaghi, C Abeli, Luchino Chessa, Francesco Pes, Bruno Cacopardo, Benedetto Maurizio Celesia, Jacopo Vecchiet, Katia Falasca, Angelo Pan, Silvia Lorenzotti, L Sighinolfi, Daniela Segala, P. Blanc, Francesca Vichi, Giovanni Cassola, Matteo Bassetti, A. Alessandrini, Nicoletta Bobbio, Giovanni Mazzarello, Miriam Lichtner, Laura Fondaco, Paolo Bonfanti, Chiara Molteni, Alessandro Chiodera, P Milini, Giuseppe Nunnari, Giovanni Francesco Pellicanò, Antonella d’Arminio Monforte, Massimo Galli, Adriano Lazzarin, Gloria Montenegro Rizzardini, Massimo Puoti, Antonella Castagna, Elvira Stefania Cannizzo, M C Moioli, R. Piolini, Dario Bernacchia, Andrea Poli, Camilla Tincati, C Mussini, Cinzia Puzzolante, C Migliorino, Giuseppe Lapadula, Vincenzo Sangiovanni, Guglielmo Borgia, Vincenzo Esposito, G Di Flumeri, Ivan Gentile, Vincent Rizzo, Anna Maria Cattelan, Serena Marinello, Antonio Cascio, Marcello Trizzino, Daniela Francisci, Elisabetta Schiaroli, Giustino Parruti, F Sozio, C Lazzaretti, R Corsini, Massimo Andreoni, Andrea Antinori, Roberto Cauda, Antonio Cristaudo, Vincenzo Vullo, R Acinapura, Silvia Lamonica, M Capozzi, Annalisa Mondi, Antonella Cingolani, Marco Rivano Capparuccia, Giancarlo Iaiani, Alessandra Latini, Giovanna Onnelli, Maria Maddalena Plazzi, Giovanni de Girolamo, Alessandra Vergori, M Cecchetto, Franco Viviani, Giordano Madeddu, Andrea De Vito, Barbara Rossetti, Francesca Montagnani, Antonina Franco, Rosario Vecchio, Giuliano Enzi, P Caramello, Giovanni Di Perri, Stefano Bonora, Giancarlo Orofino, Mariangela Sciandra, AP Londero, Vinicio Manfrin, Giuliana Battagin, Giulio Starnini, A Ialungo,

Hepatitis B Virus Studies

Abstract Background The aim of this study was to investigate the impact of anti-HBc (HBcAb) positivity on the progression of liver fibrosis (Fibrosis-4 score >3.25) in the Italian cohort of HIV-infected individuals naïve to antiretroviral treatment (ICONA). Methods All patients with FIB-4 <3.25 at baseline were evaluated prospectively: 6966 people with HIV (PWH) were screened and classified based on hepatitis B virus (HBV) and hepatitis C virus (HCV) serology. Results Patients who were HBcAb+/HCV-/HBs antigen (HBsAg)- and HCV+/HBcAb+/HBsAg- or HBsAg+/HBcAb+/HCV- had CD4+ cell counts below the nadir and significantly higher prevalence of AIDS diagnosis at baseline than the other groups (P < .0001). A Cox regression model adjusted for age, HIV transmission mode, country of birth, and alcohol consumption showed a higher relative risk (HR) of progression to FIB-4 >3.25 in HCV+/HBcAb+/HBsAg- patients (HR, 7.2; 95% CI, 3 8–13.64). Conclusions HBcAb+ contributes to liver damage in HIV+/HCV+/HBcAb+/HBsAg- subjects. A careful monitoring for signs of previous HBV infection is needed in this kind of patients.