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Antifungal activity of β-lapachone against azole-resistant Candida spp. and its aspects upon biofilm formation

2020; Future Medicine; Volume: 15; Issue: 16 Linguagem: Inglês

10.2217/fmb-2020-0011

1746-0921

Cecília Rocha da Silva, Rosana de Sousa Campos, João Batista de Andrade Neto, Sandro Serpa, Francisca Bruna Stefany Aires do Nascimento, Lívia Gurgel do Amaral Valente Sá, Thiago M Cândido, Hemerson I. F. Magalhães, Eduardo HG da Cruz, Eufrânio N. da Silva Júnior, Manoel Odorico de Moraes, Bruno C. Cavalcanti, Jacilene Silva, Emmanuel Silva Marinho, Hélio Vitoriano Nobre Júnior,

Synthesis and biological activity

Aim: The purpose of this study was to assess the antifungal effect of β-lapachone (β-lap) on azole-resistant strains of Candida spp. in both planktonic and biofilm form. Materials & methods: The antifungal activity of β-lap was evaluated by broth microdilution, flow cytometry and the comet assay. The cell viability of the biofilms was assessed using the MTT assay. Results: β-lap showed antifungal activity against resistant strains of Candida spp. in planktonic form. In addition, β-lap decreased the viability of mature biofilms and inhibited the formation of biofilms in vitro. Conclusion: β-lap showed antifungal activity against Candida spp., suggesting that the compound can be utilized as an adjunct agent in the treatment of candidiasis.