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Exercise training improves microvascular function in patients with Chagas heart disease: Data from the PEACH study

2020; Elsevier BV; Volume: 134; Linguagem: Inglês

10.1016/j.mvr.2020.104106

1095-9319

Juliana Pereira Borges, Fernanda de Souza Nogueira Sardinha Mendes, Marcus Vinícius dos Santos Rangel, Gabriella de Oliveira Lopes, Gilberto Marcelo Sperandio da Silva, Paula Simplício da Silva, Flavia Mazzoli‐Rocha, Roberto Magalhães Saraiva, Andréa Silvestre de Sousa, Eduardo Tibiriçá, Mauro Felippe Felix Mediano,

Antioxidant Activity and Oxidative Stress

Chagas heart disease (CHD) impairs the systemic microvascular function. We investigated the effects of exercise training on cutaneous microvascular function among patients with CHD. Patients from the PEACH study were randomly assigned to a supervised exercise training 3 times/week for 6 months (Trained; n = 10) or a control group (Untrained; n = 8). Both groups underwent evaluation of microvascular function before, and at 3- and 6-months of follow-up. Cutaneous vascular conductance (CVC) was assessed in the skin of the forearm using laser speckle contrast imaging coupled with iontophoresis of acetylcholine (ACh), sodium nitroprusside (SNP) and during post-occlusive reactive hyperemia (PORH). At 3-months of follow-up, no difference was detected between groups in CVC responses to ACh (p = 0.50), SNP (p = 0.26) and HRPO (p = 0.65). However, at 6-months of follow-up, trained vs. untrained patients improved CVC induced by SNP-iontophoresis (0.19 ± 0.10 vs. 0.14 ± 0.15 APU.mmHg−1; p = 0.05) and PORH (0.63 ± 0.15 vs. 0.48 ± 0.18 APU.mmHg−1; p = 0.05). CVC response to ACh-iontophoresis was similar between groups (0.19 ± 0.11 vs. 0.22 ± 0.17 APU.mmHg−1; p = 0.38). Exercise training performed during 6 months improved the cutaneous microvascular function of CHD patients. Further studies evaluating the mechanism involved in this response are warranted.