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BIBTEX RIS

Relevance of angiotensin-(1-7) and its receptor Mas in pneumonia caused by influenza virus and post-influenza pneumococcal infection

2020; Elsevier BV; Volume: 163; Linguagem: Inglês

10.1016/j.phrs.2020.105292

ISSN

1096-1186

Autores

Eliza Mathias Melo, Juliana Del Sarto, Juliana P. Vago, Luciana P. Tavares, Flávia Rago, Ana Paula Gonçalves, Marina Gomes Machado, Irene Aranda-Pardos, Bruno Vinícius Santos Valiate, Geovanni Dantas Cassali, Vanessa Pinho, Lirlândia P. Sousa, Noelia A-González, Maria José Campagnole‐Santos, Michael Bäder, Robson A.S. Santos, Alexandre V. Machado, Stephan Ludwig, Mauro Martins Teixeira,

Tópico(s)

SARS-CoV-2 and COVID-19 Research

Resumo

Resolution failure of exacerbated inflammation triggered by Influenza A virus (IAV) prevents return of pulmonary homeostasis and survival, especially when associated with secondary pneumococcal infection. Therapeutic strategies based on pro-resolving molecules have great potential against acute inflammatory diseases. Angiotensin-(1-7) [Ang-(1-7)] is a pro-resolving mediator that acts on its Mas receptor (MasR) to promote resolution of inflammation. We investigated the effects of Ang-(1-7) and the role of MasR in the context of primary IAV infection and secondary pneumococcal infection and evaluated pulmonary inflammation, virus titers and bacteria counts, and pulmonary damage. Therapeutic treatment with Ang-(1-7) decreased neutrophil recruitment, lung injury, viral load and morbidity after a primary IAV infection. Ang-(1-7) induced apoptosis of neutrophils and efferocytosis of these cells by alveolar macrophages, but had no direct effect on IAV replication in vitro. MasR-deficient (MasR

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