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BIBTEX RIS

T-Cell Immune Surveillance in Allogenic Stem Cell Transplant Recipients: Are Whole Blood–Based Assays Ready to Challenge ELISPOT?

2020; Oxford University Press; Volume: 8; Issue: 1 Linguagem: Inglês

10.1093/ofid/ofaa547

ISSN

2328-8957

Autores

Chris D. Lauruschkat, Lukas Page, Sonja Etter, Philipp Weis, Florian Gamon, Sabrina Kraus, Hermann Einsele, Sebastian Wurster, Juergen Loeffler,

Tópico(s)

Fungal Infections and Studies

Resumo

Abstract We compared the feasibility of 4 cytomegalovirus (CMV)- and Aspergillus-reactive T-cell immunoassay protocols in allogenic stem cell transplant recipients. While enzyme-linked immunospot performed best overall, logistically advantageous whole blood–based assays performed comparably in patients with less severe lymphocytopenia. CMV-induced interferon-gamma responses correlated strongly across all protocols and showed high concordance with serology.

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