Portal de Periódicos da CAPES

DESENVOLVIMENTO NOS MÉTODOS DE GLICOSILAÇÃO: UMA CHAVE PARA ACESSAR SUAS APLICAÇÕES NA SÍNTESE DE MOLÉCULAS BIOATIVAS

2020; Brazilian Chemical Society; Linguagem: Inglês

10.21577/0100-4042.20170676

1678-7064

Pedro Ramos de Souza Neto, Bruna Martins Guimarães, Jucleiton José Rufino de Freitas, Ronaldo N. de Oliveira, João Freitas Filho,

Enzyme Production and Characterization

DEVELOPMENT IN GLYCOSYLATION METHODS: A KEY TO ACCESS ITS APPLICATIONS IN THE SYNTHESIS OF BIOACTIVE MOLECULES. Glycosylation reaction is an important class of reactions in organic chemistry, and the development of the method contributes to the synthesis of many biologically active compounds containing various glycoside bonds. Is arguably the most important, albeit challenging, reaction in the field of carbohydrate chemistry. Examples of the products of glycosylation reactions are glycoproteins, glycolipids, glycosaminoglycans, oligosaccharides, and polysaccharides. Glycosylation types are classified according to the identity of the atom which binds the carbohydrate chain, i.e. C-linked, N-linked, O-linked or S-linked. In this short review, recent reports of the main glycosylation methods, basic mechanisms, factors influencing the stereoselectivity and their applications in the synthesis of bioactive molecules are described.