Produção Nacional
Revisado por pares
Gamma-oryzanol as a potential modulator of oxidative stress and inflammation via PPAR-y in adipose tissue: a hypothetical therapeutic for cytokine storm in COVID-19?
2020; Elsevier BV; Volume: 520; Linguagem: Inglês
10.1016/j.mce.2020.111095
ISSN1872-8057
AutoresFabiane Valentini Francisqueti-Ferron, Jéssica Leite Garcia, Artur Júnio Togneri Ferron, Erika Tiemi Nakandakare-Maia, Cristina Schmitt Gregolin, Janaina Paixão das Chagas Silva, Klinsmann Carolo dos Santos, Ângelo Thompson Colombo Lo, Juliana Silva Siqueira, Letícia de Mattei, Bruno Henrique de Paula, Felipe Sarzi, Carol Cristina Vágula de Almeida Silva, Fernando Moreto, Mariane Róvero Costa, Ana Lúcia Anjos Ferreira, Igor Otávio Minatel, Camila Renata Corrêa,
Tópico(s)COVID-19 Clinical Research Studies
ResumoThe literature has reported a higher prevalence of negative clinical outcomes due to Coronavirus disease 19 (COVID-19) in obese individuals. This can be explained by the cytokine storm, result from the cytokine production from both obesity and viral infection. Gamma-oryzanol (γOz) is a compound with anti-inflammatory and antioxidant activities. However, little is known about the γOz action as a possible agonist of peroxisome proliferator-activated receptor gamma (PPAR-γ). The aim of this study was to test the hypothesis that γOz attenuates the cytokine storm by stimulating PPAR-γ in the adipose tissue. Methods: Male Wistar rats were randomly divided into three experimental groups and fed ad libitum for 30 weeks with control diet (C, n = 6), high sugar-fat diet (HSF, n = 6) or high sugar-fat diet + γOz (HSF + γOz, n = 6). HSF groups also received water + sucrose (25%). The γOz dose was 0.5% in the chow. Evaluation in animals included caloric intake, body weight, adiposity index, plasma triglycerides, and HOMA-IR. In adipose tissue was evaluated: PPAR-γ gene and protein expression, inflammatory and oxidative stress parameters, and histological analysis. Results: Adipose tissue dysfunction was observed in HSF group, which presented remarkable PPAR-γ underexpression and increased levels of cytokines, other inflammatory markers and oxidative stress. The γOz treatment prevented adipose tissue dysfunction and promoted PPAR-γ overexpression. Conclusion: Natural compounds as γOz can be considered a coadjutant therapy to prevent the cytokine storm in COVID-19 patients with obesity conditions.
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